Curated repository for small angle scattering data and models


SASBDB currently contains:


4370

experimental data sets

5703

models
536 experimental data sets on hold
635 models on hold

Small angle scattering (SAS) of X-ray and neutrons provides structural information on biological macromolecules in solution at a resolution of 1-2 nm.
SASBDB is a fully searchable curated repository of freely accessible and downloadable experimental data, which are deposited together with the relevant experimental conditions, sample details, derived models and their fits to the data.

Recent depositions:

SASDVM2 – Ternary complex consisted of Human Neutrophil elastase tetramer and S.aureus Protein map Eap4-domain-4 (Δ347-476Δ) (Complex: NE/Eap4/NE)

Neutrophil elastaseProtein map experimental SAS data
PHENIX model
Sample: Neutrophil elastase tetramer, 93 kDa Homo sapiens protein
Protein map dimer, 24 kDa Staphylococcus aureus (strain … protein
Buffer: 20 mM HEPES, 140 mM NaCl, pH: 7.4
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2023 Jun 26
S. aureus Eap is a polyvalent inhibitor of neutrophil serine proteases. J Biol Chem 300(9):107627 (2024)
Mishra N, Gido CD, Herdendorf TJ, Hammel M, Hura GL, Fu ZQ, Geisbrecht BV
RgGuinier 3.7 nm
Dmax 11.0 nm
VolumePorod 163 nm3

BTB domain of longitudinals lacking (LOLA) protein
Longitudinals lacking protein, isoform G experimental SAS data
The Arthropoda-specific Tramtrack group BTB protein domains use previously unknown interface to form hexamers. Elife 2024 Sep 2;13
Elife 13 (2024 Sep 2)
mRNA capping enzyme MTase
Virus termination factor small subunitmRNA-capping enzyme catalytic subunit experimental SAS data
Structural basis of the monkeypox virus mRNA cap N7 methyltransferase complex. Emerg Microbes Infect 2024 Dec;13(1):2369193
Emerg Microbes Infect 13(1):2369193 (2024 Dec)
Calcium/calmodulin-dependent protein kinase type II alpha (CaMKIIα) WT hub domain with PIPA (ii-remeasured after storage)
Calcium/calmodulin-dependent protein kinase type II subunit alpha2-(6-(4-chlorophenyl)imidazo[1,2-b]pyridazine-2-yl)acetic acid experimental SAS data
Ligand‐induced CaMKIIα hub Trp403 flip, hub domain stacking, and modulation of kinase activity Protein Science 2024 Sep 14 33(10)
Protein Science 33(10) (2024 Sep 14)
Glucose-regulated protein 78 nucleotide-binding domain (GRP78-NBD) in complex with the C-terminal of Cerebral dopamine neurotrophic factor (C-CDNF)
Endoplasmic reticulum chaperone BiPC-terminal of the Cerebral dopamine neurotrophic factor experimental SAS data
Structural basis of CDNF interaction with the UPR regulator GRP78. Nat Commun 2024 Sep 18;15(1):8175
Nat Commun 15(1):8175 (2024 Sep 18)
Streptococcus pyogenes Protein-ADP-ribose hydrolase: glycine cleavage system H-like protein complex
Glycine cleavage system H-like proteinProtein-ADP-ribose hydrolase (D13G, Y23S, T61A, I114S, R177H, I246T) experimental SAS data
Evolutionary and molecular basis of ADP-ribosylation reversal by zinc-dependent macrodomains Journal of Biological Chemistry 2024 Sep :107770
Journal of Biological Chemistry :107770 (2024 Sep)

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To cite SASBDB refer to: Kikhney AG, Borges CR, Molodenskiy DS, Jeffries CM, Svergun DI (2020) SASBDB: Towards an automatically curated and validated repository for biological scattering data. Protein Science 29(1); 66-75.