Curated repository for small angle scattering data and models


SASBDB currently contains:


4384

experimental data sets

5719

models
580 experimental data sets on hold
706 models on hold

Small angle scattering (SAS) of X-ray and neutrons provides structural information on biological macromolecules in solution at a resolution of 1-2 nm.
SASBDB is a fully searchable curated repository of freely accessible and downloadable experimental data, which are deposited together with the relevant experimental conditions, sample details, derived models and their fits to the data.

Recent depositions:

SASDU98 – SEC-SAXS of the fusion protein MPB-MabR(Rv2242) - dimeric peak

Maltose/maltodextrin-binding periplasmic protein (D108A, K109A, E198A, N199A, K265A)Uncharacterized protein Rv2242 experimental SAS data
ALPHAFOLD model
Sample: Maltose/maltodextrin-binding periplasmic protein (D108A, K109A, E198A, N199A, K265A) dimer, 80 kDa Escherichia coli (strain … protein
Uncharacterized protein Rv2242 dimer, 86 kDa Mycobacterium tuberculosis (strain … protein
Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, pH:
Experiment: SAXS data collected at SWING, SOLEIL on 2024 Apr 3
Domain architecture of the Mycobacterium tuberculosis MabR (Rv2242), a member of the PucR transcription factor family Heliyon :e40494 (2024)
Megalizzi V, Tanina A, Grosse C, Mirgaux M, Legrand P, Mirandela G, Wohlkönig A, Bifani P, Wintjens R
RgGuinier 3.7 nm
Dmax 10.8 nm
VolumePorod 345 nm3

Full-length SARS-CoV-2 5'ge element stem-loop 5 (5_SL5)
full stem-loop 5 of SARS-CoV-2 5'genomic end experimental SAS data
Dissecting the Conformational Heterogeneity of Stem-Loop Substructures of the Fifth Element in the 5'-Untranslated Region of SARS-CoV-2. J Am Chem Soc 2024 Nov 6;146(44):30139-30154
J Am Chem Soc 146(44):30139-30154 (2024 Nov 6)
S9 carboxypeptidase from Bacillus subtilis (4 mg/ml)
Putative acylaminoacyl-peptidase experimental SAS data
Structural adaptations for carboxypeptidase activity in putative S9 acylaminoacyl peptidase from Bacillus subtilis. Int J Biol Macromol 2024 Oct 19;:136734
Int J Biol Macromol :136734 (2024 Oct 19)
Cereblon-midi (CRBNmidi), an engineered Cereblon construct for crystallographic and biophysical studies, bound to Mezigdomide
Cereblon-midimezigdomide experimental SAS data
Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders Nature Communications 2024 Oct 15 15(1)
Nature Communications 15(1) (2024 Oct 15)
Ternary complex consisted of Human Neutrophil elastase tetramer and S.aureus Protein map Eap4-domain-4 (Δ347-476Δ) (Complex: NE/Eap4/NE)
Neutrophil elastaseProtein map experimental SAS data
S. aureus Eap is a polyvalent inhibitor of neutrophil serine proteases. J Biol Chem 2024 Aug 3;300(9):107627
J Biol Chem 300(9):107627 (2024 Aug 3)
BTB domain of longitudinals lacking (LOLA) protein
Longitudinals lacking protein, isoform G experimental SAS data
The Arthropoda-specific Tramtrack group BTB protein domains use previously unknown interface to form hexamers. Elife 2024 Sep 2;13
Elife 13 (2024 Sep 2)

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To cite SASBDB refer to: Kikhney AG, Borges CR, Molodenskiy DS, Jeffries CM, Svergun DI (2020) SASBDB: Towards an automatically curated and validated repository for biological scattering data. Protein Science 29(1); 66-75.