Synchrotron SAXS data from solutions of SARS-CoV-2 5' untranslated region stem-loop 4 RNA (5_SL4) in 25 mM potassium phosphate pH 6.5, 150 mM KCl, 2 mM TCEP, were collected on the EMBL P12 beam line at PETRA III (DESY, Hamburg, Germany) using a Pilatus 6M detector at a sample-detector distance of 3 m and at a wavelength of λ = 0.124028 nm (I(s) vs s, where s = 4πsinθ/λ, and 2θ is the scattering angle). One solute concentration of 4.50 mg/ml was measured at 20°C. 40 successive 0.095 second frames were collected. The data were normalized to the intensity of the transmitted beam and radially averaged; the scattering of the solvent-blank was subtracted.