Transient receptor potential cation channel subfamily V member 4

TRPV4 protein

Organism: Gallus gallus

Monomeric molecular weight: 42.5 kDa

Oligomeric state: Monomer

Total molecular weight: 42.5 kDa

UniProt: A0A1D5PXA5 (2-382)

Sequence:

ADPEDPRDAGDVLGDDSFPLSSLANLFEVEDTPSPAEPSRGPPGAVDGKQNLRMKFHGAFRKGPPKPMELLESTIYESSVVPAPKKAPMDSLFDYGTYRQHPSENAAWAARVVEKPVAGTKGPAPNPPPILKVFNRPILFDIVSRGSPDGLEGLLSFLLTHKKRLTDEEFREPSTGKTteCLPKALLNLSAGRNDTIPILLDIAEKTGNMREFINSPFRDVYYRGQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVHYLTENGHKQADLRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLIKCAKLFPDTNLEALLNNDGLSPLMMAAKTGKIGIFQHIIRREIAD

The molecule contains residues A2-D382 of G. gallus TRPV4, which includes an intrinsically disordered region with a mutated PIP2 binding site (107KRWRR111 to 107AAWAA111) followed by an Ankryin repeat domain (F135-382).