Regulator of telomere elongation helicase 1 (Isoform 6, 756-1300)
RETL-1, CT-L protein
Organism: Homo sapiens
Monomeric molecular weight: 58.5 kDa
Oligomeric state:
Monomer
Total molecular weight: 58.5 kDa
RTEL1 is an essential DNA helicase that prevents chromosome ends instability by disassembling telomere loops and suppressing telomere fragility, as well as playing a role in DNA replication and repair. It comprises a long C-terminal region that plays a crucial role in cell metabolism mediating RTEL1 interaction with factors involved in pivotal cellular pathways. This region includes a few small folded domains (two helical repeats and a RING finger domain) connected by partially unstructured regions