Gag-Pol polyprotein (588-1027: Reverse transcriptase p51; p51 RT)

p51 protein

Organism: Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)

Monomeric molecular weight: 53.5 kDa

Oligomeric state: Monomer

Total molecular weight: 53.5 kDa

UniProt: P04585 (588-1027)

Sequence:

MNHKVHHHHHHLEGRHMPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETF

Proteolytic cleavage of p66 removes the RNase H domain to yield the p51 RT subunit. The protein construct used for SAXS contains a N-terminal polyhistidine tag.