Calcium/calmodulin-dependent protein kinase type II subunit alpha (T354N, E355Q, T412N, I414M, I464H, F467M)

CaMKIIα 6x hub protein

Organism: Homo sapiens

Monomeric molecular weight: 15.5 kDa

Oligomeric state: 14-mer

Total molecular weight: 217.4 kDa

UniProt: Q9UQM7 (345-475)

Sequence:

GPHMVRKQEIIKVNQQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHNTMLNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQHVHMHRSGAPSV

6 x mutation of WT hub : T354N, E355Q, T412N, I414M, I464H, F467M. The protein construct used for SAXS contains an additional four non-native amino acids at the N-terminus (GPHM).