Apoptosis-inducing factor 1, mitochondrial

AIF protein

Organism: Homo sapiens

Monomeric molecular weight: 56.3 kDa

Oligomeric state: Dimer

Total molecular weight: 112.7 kDa

UniProt: O95831 (104-613)

Sequence:

MLTPEQKQKKAALSASEGEEVPQDKAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLRFKQANGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARALGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIPPSTPAVPQAPVQGEDYGKGVIFYLRDKVVVGIVLWNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHEDSGSGPGSGS

This molecule is a fusion of AIF(104-613)-W196A and the N-terminus of CHCHD4 (residues 1-45) connected by a peptide linker (SGSGPGSGS). The chimera retains residues LEVLFQ at the C-terminus from the fusion tag.