Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.

Felix J, Kandiah E, De Munck S, Bloch Y, van Zundert GC, Pauwels K, Dansercoer A, Novanska K, Read RJ, Bonvin AM, Vergauwen B, Verstraete K, Gutsche I, Savvides SN
Nat Commun 7:13228 (2016 Nov 7)
PMID: 27819269
doi: 10.1038/ncomms13228 		Submitted to SASBDB: 2015 Aug 7
Published in SASBDB:

SASDA89 – Complex between ovine GM-CSF and GM-CSF/IL-2 inhibition factor

GM-CSF/IL-2 inhibition factorGranulocyte-macrophage colony-stimulating factor experimental SAS data
NONE model
Sample: GM-CSF/IL-2 inhibition factor tetramer, 120 kDa Orf virus protein
Granulocyte-macrophage colony-stimulating factor dimer, 29 kDa Ovis aries protein
Buffer: 20 mM HEPES 150 mM NaCl, pH: 7.4
Experiment: SAXS data collected at SWING, SOLEIL on 2014 Sep 10
RgGuinier 3.8 nm
Dmax 12.4 nm
VolumePorod 231 nm3

SASDA99 – Complex between ovine IL-2 and GM-CSF/IL-2 inhibition factor

GM-CSF/IL-2 inhibition factorInterleukin-2 experimental SAS data
NONE model
Sample: GM-CSF/IL-2 inhibition factor tetramer, 120 kDa Orf virus protein
Interleukin-2 monomer, 16 kDa Ovis aries protein
Buffer: 20 mM HEPES 150 mM NaCl, pH: 7.4
Experiment: SAXS data collected at SWING, SOLEIL on 2014 Sep 10
RgGuinier 4.1 nm
Dmax 12.9 nm
VolumePorod 253 nm3