Structural Mimicry Drives HIV-1 Rev-Mediated HERV-K Expression

O'Carroll I, Fan L, Kroupa T, McShane E, Theodore C, Yates E, Kondrup B, Ding J, Martin T, Rein A, Wang Y
Journal of Molecular Biology 432(24):166711 (2020 Dec)

doi: 10.1016/j.jmb.2020.11.010

Submitted to SASBDB: 2020 Apr 4 Published in SASBDB: 2023 Jul 17

SASDHL9 – Full-length HERV-K Rec response element Sample: Full-length HERV-K Rec response element monomer, 141 kDa Homo sapiens RNA Buffer: 10mM Tris-HCl, 100mM KCl, and 0.5mM MgCl₂, pH: 8 Experiment: SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2018 Feb 10 RgGuinier 7.5 nm Dmax 28.2 nm VolumePorod 454 nm3

SASDHM9 – Truncated HERV-K Rec response element (RcRE) RNA Sample: Truncated HERV-K Rec response element monomer, 102 kDa Homo sapiens RNA Buffer: 10mM Tris-HCl, 100mM KCl, and 0.5mM MgCl₂, pH: 8 Experiment: SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2018 Jul 17 RgGuinier 6.1 nm Dmax 21.8 nm VolumePorod 322 nm3

SASDHN9 – TrΔSLIII HERV-K Rec response element (RcRE) RNA Sample: TrΔSLIII HERV-K Rec response element monomer, 88 kDa Homo sapiens RNA Buffer: 10mM Tris-HCl, 100mM KCl, and 0.5mM MgCl₂, pH: 8 Experiment: SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2018 Dec 7 RgGuinier 5.3 nm Dmax 19.2 nm VolumePorod 226 nm3

SASDHP9 – TrΔSLIIab HERV-K Rec response element (RcRE) RNA Sample: TrΔSLIIab HERV-K Rec response element monomer, 86 kDa Homo sapiens RNA Buffer: 10mM Tris-HCl, 100mM KCl, and 0.5mM MgCl₂, pH: 8 Experiment: SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Feb 21 RgGuinier 5.0 nm Dmax 18.4 nm VolumePorod 201 nm3