The Role of Small-Angle X-Ray Scattering and Molecular Simulations in 3D Structure Elucidation of a DNA Aptamer Against Lung Cancer

Morozov D, Mironov V, Moryachkov R, Shchugoreva I, Artyushenko P, Zamay G, Kolovskaya O, Zamay T, Krat A, Molodenskiy D, Zabluda V, Veprintsev D, Sokolov A, Zukov R, Berezovski M, Tomilin F, Fedorov D, Alexeev Y, Kichkailo A
Molecular Therapy - Nucleic Acids (2021 Jul)

doi: 10.1016/j.omtn.2021.07.015

Submitted to SASBDB: 2020 Dec 22 Published in SASBDB: 2021 Aug 3

SASDK36 – LC-18t - ssDNA aptamer specific to lung adenocarcinoma cancer cells Sample: Lung adenocarcinoma aptamer, truncated version monomer, 11 kDa Artificially synthesized DNA Buffer: Phosphate-buffered saline, pH: 7.4 Experiment: SAXS data collected at EMBL P12, PETRA III on 2018 Oct 28 RgGuinier 2.1 nm Dmax 6.7 nm VolumePorod 16 nm3