Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.

Lim SA, Zhou J, Martinko AJ, Wang YH, Filippova EV, Steri V, Wang D, Remesh SG, Liu J, Hann B, Kossiakoff AA, Evans MJ, Leung KK, Wells JA
J Clin Invest 132(4) (2022 Feb 15)
PMID: 35166238
doi: 10.1172/JCI154604 		Submitted to SASBDB: 2021 Feb 9
Published in SASBDB:

SASDKJ8 – CUB domain-containing protein 1 (CDCP1)

CUB domain-containing protein 1 experimental SAS data
CUB domain-containing protein 1 Kratky plot
Sample: CUB domain-containing protein 1 monomer, 77 kDa Homo sapiens protein
Buffer: 10 mM phosphate, 137 mM NaCl, 2.7 mM KCl,, pH: 7.4
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Jul 29
RgGuinier 4.4 nm
Dmax 14.5 nm
VolumePorod 185 nm3

SASDKK8 – Cleaved CUB domain containing protein 1 (CDCP1)

Cleaved - CUB domain-containing protein 1 (N-terminus)Cleaved - CUB domain-containing protein 1 (C-terminus) experimental SAS data
Cleaved - CUB domain-containing protein 1 (N-terminus) Cleaved - CUB domain-containing protein 1 (C-terminus) Kratky plot
Sample: Cleaved - CUB domain-containing protein 1 (N-terminus) monomer, 38 kDa Homo sapiens protein
Cleaved - CUB domain-containing protein 1 (C-terminus) monomer, 39 kDa Homo sapiens protein
Buffer: 10 mM phosphate, 137 mM NaCl, 2.7 mM KCl,, pH: 7.4
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Jul 29
RgGuinier 4.4 nm
Dmax 14.3 nm
VolumePorod 182 nm3