Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti.

Saucereau Y, Wilson TH, Tang MCK, Moncrieffe MC, Hardwick SW, Chirgadze DY, Soares SG, Marcaida MJ, Gay NJ, Gangloff M
Nat Commun 13(1):5110 (2022 Aug 30)
PMID: 36042238
doi: 10.1038/s41467-022-32690-6 		Submitted to SASBDB: 2021 Feb 23
Published in SASBDB:

SASDKX8 – Aedes aegypti Toll5A receptor ectodomain (T5A)

Toll-like receptor experimental SAS data
Toll-like receptor Kratky plot
Sample: Toll-like receptor dimer, 175 kDa Aedes aegypti protein
Buffer: 50 mM NaCl, 50 mM Tris-HCl, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2019 Aug 2
RgGuinier 5.4 nm
Dmax 20.5 nm
VolumePorod 370 nm3

SASDKY8 – Aedes aegypti Toll5A ectodomain in complex with Spz1C Cys-knot domain

Toll-like receptorAAEL013433-PA (Cystine-knot_cytokine) experimental SAS data
Toll-like receptor AAEL013433-PA (Cystine-knot_cytokine) Kratky plot
Sample: Toll-like receptor dimer, 175 kDa Aedes aegypti protein
AAEL013433-PA (Cystine-knot_cytokine) dimer, 26 kDa Aedes aegypti protein
Buffer: 50 mM NaCl, 50 mM Tris-HCl, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2019 Aug 2
RgGuinier 5.5 nm
Dmax 21.5 nm
VolumePorod 567 nm3