Crystal Structure of the Brugia malayi Thymidylate Kinase-dTMP Complex and Small Angle X-ray Scattering Experiments Identifies Changes in the Dimeric Association Compared to the Human Homolog

Vishwakarma J, Sharma V, Kumar S, Ramachandran R
Crystallography Reports 68(7):1150-1158 (2024 Feb 06)

doi: 10.1134/S1063774521100400 		Submitted to SASBDB: 2021 Mar 2
Published in SASBDB:

SASDKU9 – Thymidylate kinase (dTMP kinase) at pH 8.0

dTMP kinase experimental SAS data
GASBOR model
Sample: DTMP kinase dimer, 57 kDa Brugia malayi protein
Buffer: 20 mM Tris, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at Anton Paar SAXSpace, CSIR-Central Drug Research Institute on 2018 Oct 7
RgGuinier 3.0 nm
Dmax 8.4 nm
VolumePorod 81 nm3