Albumin in patients with liver disease shows an altered conformation.

Paar M, Fengler VH, Rosenberg DJ, Krebs A, Stauber RE, Oettl K, Hammel M
Commun Biol 4(1):731 (2021 Jun 14)

PMID: 34127764 doi: 10.1038/s42003-021-02269-w

Submitted to SASBDB: 2021 Apr 15 Published in SASBDB: 2021 Apr 20

SASDLC4 – Human Albumin (HSA) Healthy donor used for HNA1, HNA2, HMA fractions Sample: Albumin monomer, 69 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM KCl, 2% glycerol, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Dec 1 RgGuinier 2.8 nm Dmax 8.5 nm

SASDL24 – Human Albumin (HMA) Sample: Albumin monomer, 69 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM KCl, 2% glycerol, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Dec 1 RgGuinier 2.8 nm Dmax 9.2 nm

SASDL34 – Human Albumin (HNA1) Sample: Albumin monomer, 69 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM KCl, 2% glycerol, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Dec 1 RgGuinier 2.9 nm Dmax 8.9 nm

SASDL44 – Human Albumin (HNA2) Sample: Albumin monomer, 69 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM KCl, 2% glycerol, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Dec 1 RgGuinier 2.8 nm Dmax 8.1 nm

SASDLU3 – Human Albumin (C1) Sample: Albumin monomer, 69 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM KCl, 2% glycerol, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Dec 1 RgGuinier 2.7 nm Dmax 8.2 nm

SASDLV3 – Human Albumin (C2) Sample: Albumin monomer, 69 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM KCl, 2% glycerol, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Dec 1 RgGuinier 2.8 nm Dmax 8.3 nm

SASDLW3 – Human Albumin (C3) Sample: Albumin monomer, 69 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM KCl, 2% glycerol, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Dec 1 RgGuinier 2.8 nm Dmax 8.3 nm

SASDLX3 – Human Albumin (C4) Sample: Albumin monomer, 69 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM KCl, 2% glycerol, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Dec 1 RgGuinier 2.8 nm Dmax 8.4 nm

SASDLY3 – Human Albumin (C6) control SIGMA Sample: Albumin monomer, 69 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM KCl, 2% glycerol, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Dec 1 RgGuinier 2.8 nm

SASDLZ3 – Human Albumin (C6) control SIGMA Sample: Albumin monomer, 69 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM KCl, 2% glycerol, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Dec 1 RgGuinier 2.8 nm

SASDL54 – Human Albumin (P1) Sample: Albumin monomer, 69 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM KCl, 2% glycerol, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Dec 1 RgGuinier 2.9 nm Dmax 9.3 nm

SASDL64 – Human Albumin (P2) Sample: Albumin monomer, 69 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM KCl, 2% glycerol, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Dec 1 RgGuinier 2.9 nm Dmax 9.4 nm

SASDL74 – Human Albumin (P3) patient Sample: Albumin monomer, 69 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM KCl, 2% glycerol, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Dec 1 RgGuinier 2.9 nm Dmax 8.7 nm

SASDL84 – Human Albumin (P4) Sample: Albumin monomer, 69 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM KCl, 2% glycerol, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Dec 1 RgGuinier 2.9 nm Dmax 9.0 nm

SASDL94 – Human Albumin (P5) Sample: Albumin monomer, 69 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM KCl, 2% glycerol, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Dec 1 RgGuinier 2.9 nm Dmax 8.9 nm

SASDLA4 – Human Albumin (P6) Sample: Albumin monomer, 69 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM KCl, 2% glycerol, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Dec 1 RgGuinier 2.8 nm Dmax 8.5 nm

SASDLD4 – Human Albumin (P7) Sample: Albumin monomer, 69 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM KCl, 2% glycerol, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Dec 1 RgGuinier 2.8 nm Dmax 9.2 nm

SASDLE4 – Human Albumin (P9) Sample: Albumin monomer, 69 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM KCl, 2% glycerol, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Dec 1 RgGuinier 2.8 nm Dmax 8.9 nm