Solution structures of human myeloma IgG3 antibody reveal extended Fab and Fc regions relative to the other IgG subclasses.

Spiteri VA, Goodall M, Doutch J, Rambo RP, Gor J, Perkins SJ
J Biol Chem :100995 (2021 Jul 21)
PMID: 34302810
doi: 10.1016/j.jbc.2021.100995 		Submitted to SASBDB: 2021 Apr 6
Published in SASBDB:

SASDLZ2 – Immunoglobulin G3 (IgG3) Glycosylated

Immunoglobulin G subclass 3 experimental SAS data
CUSTOM IN-HOUSE model
Sample: Immunoglobulin G subclass 3 monomer, 155 kDa Homo sapiens protein
Buffer: 20 mM L-histidine, 138 mM NaCl, and 2.6 mM KCl buffer, pH: 6
Experiment: SAXS data collected at B21, Diamond Light Source on 2019 Jul 29
RgGuinier 7.0 nm
Dmax 22.9 nm
VolumePorod 267 nm3

SASDL23 – Immunoglobulin G3 (IgG3) Deglycosylated

Immunoglobulin G subclass 3 experimental SAS data
CUSTOM IN-HOUSE model
Sample: Immunoglobulin G subclass 3 monomer, 155 kDa Homo sapiens protein
Buffer: 20 mM L-histidine, 138 mM NaCl, and 2.6 mM KCl buffer, pH: 6
Experiment: SAXS data collected at B21, Diamond Light Source on 2019 Jul 29
RgGuinier 7.1 nm
Dmax 27.7 nm
VolumePorod 294 nm3