High Density of N- and O-Glycosylation Shields and Defines the Structural Dynamics of the Intrinsically Disordered Ectodomain of Receptor-type Protein Tyrosine Phosphatase Alpha

Chien Y, Wang Y, Sridharan D, Kuo C, Chien C, Uchihashi T, Kato K, Angata T, Meng T, Hsu S, Khoo K
JACS Au (2023 Jun 13)

doi: 10.1021/jacsau.3c00124 		Submitted to SASBDB: 2024 Jun 24
Published in SASBDB:

SASDV53 – Fc-fused PTPRA ECD in PBS buffer

Receptor-type tyrosine-protein phosphatase alpha experimental SAS data
DAMMIF model
Sample: Receptor-type tyrosine-protein phosphatase alpha dimer, 150 kDa Homo sapiens protein
Buffer: 10 mM phosphate, 137 mM NaCl, 2.7 mM KCl, pH: 7.4
Experiment: SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2021 Aug 19
RgGuinier 8.3 nm
Dmax 35.3 nm