Structure of PLA2R reveals presentation of the dominant membranous nephropathy epitope and an immunogenic patch

Fresquet M, Lockhart-Cairns M, Rhoden S, Jowitt T, Briggs D, Baldock C, Brenchley P, Lennon R
Proceedings of the National Academy of Sciences 119(29) (2022 Jul 11)

doi: 10.1073/pnas.2202209119

Submitted to SASBDB: 2021 Dec 23 Published in SASBDB: 2022 Jul 12

SASDNP3 – Recombinant phospholipase A2 receptor at pH 7.2 Sample: Secretory phospholipase A2 receptor monomer, 189 kDa Homo sapiens protein Buffer: 10 mM Bis-Tris, 150 mM NaCl, pH: 7.2 Experiment: SAXS data collected at B21, Diamond Light Source on 2019 Dec 19 RgGuinier 5.9 nm Dmax 26.0 nm VolumePorod 504 nm3

SASDNQ3 – Recombinant phospholipase A2 receptor at pH 6.2 Sample: Secretory phospholipase A2 receptor monomer, 189 kDa Homo sapiens protein Buffer: 10 mM Bis-Tris, 150 mM NaCl, pH: 6.2 Experiment: SAXS data collected at B21, Diamond Light Source on 2019 Dec 19 RgGuinier 4.2 nm Dmax 15.8 nm VolumePorod 426 nm3