A macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target

Schiering N, D'Arcy A, Villard F, Simic O, Kamke M, Monnet G, Hassiepen U, Svergun D, Pulfer R, Eder J, Raman P, Bodendorf U
Proceedings of the National Academy of Sciences 108(52):21052-21056 (2011 Dec 12)

doi: 10.1073/pnas.1110534108 		Submitted to SASBDB: 2021 Dec 6
Published in SASBDB:

SASDML9 – Structure of bifunctional protease-helicase NS3/4A domain assembly in solution

Genome polyprotein experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Genome polyprotein dimer, 137 kDa Hepatitis C virus … protein
Buffer: 25 mM Tris, 1 M NaCl, 10% glycerol, 1 mM TCEP, 0.1% β-octyl glucoside, pH: 7.5
Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2007 Dec 12
RgGuinier 3.9 nm