Evidence of Reciprocal Reorientation of the Catalytic and Hemopexin-Like Domains of Full-Length MMP-12

Bertini I, Calderone V, Fragai M, Jaiswal R, Luchinat C, Melikian M, Mylonas E, Svergun D
Journal of the American Chemical Society 130(22):7011-7021 (2008 May 09)

doi: 10.1021/ja710491y

Submitted to SASBDB: 2021 Dec 14 Published in SASBDB: 2021 Dec 15

SASDNC2 – NNGH-inhibited, cadmium(II)-substituted Phe171Asp/Glu219Ala double mutant of FL-MMP- 12 Sample: Macrophage metalloelastase monomer, 54 kDa Homo sapiens protein Buffer: 20 mM Tris10 mM CaCl2, 0.3 M NaCl, 0.2 M AHA, pH: 7.2 Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2007 Oct 2 RgGuinier 3.2 nm Dmax 11.0 nm VolumePorod 58 nm3