Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium.

Léger C, Pitard I, Sadi M, Carvalho N, Brier S, Mechaly A, Raoux-Barbot D, Davi M, Hoos S, Weber P, Vachette P, Durand D, Haouz A, Guijarro JI, Ladant D, Chenal A
BMC Biol 20(1):176 (2022 Aug 9)

PMID: 35945584 doi: 10.1186/s12915-022-01381-5

Submitted to SASBDB: 2022 Jan 10 Published in SASBDB: 2022 Jul 22

SASDNX3 – Calcium-bound Calmodulin, including structural models Sample: Calmodulin-1 monomer, 17 kDa Homo sapiens protein Buffer: 20 mM Hepes, 150 mM NaCl, 2 mM CaCl2, pH: 7.4 Experiment: SAXS data collected at SWING, SOLEIL on 2020 Nov 15 RgGuinier 2.2 nm Dmax 7.2 nm VolumePorod 33 nm3

SASDNY3 – Calcium-bound Calmodulin complexed with Calmidazolium Sample: Calmodulin-1 monomer, 17 kDa Homo sapiens protein Calmidazolium monomer, 1 kDa Buffer: 20 mM Hepes, 150 mM NaCl, 2 mM CaCl2, pH: 7.4 Experiment: SAXS data collected at SWING, SOLEIL on 2020 Nov 15 RgGuinier 1.7 nm Dmax 5.2 nm VolumePorod 30 nm3