Mechanism of CK2 Inhibition by a Ruthenium-Based Polyoxometalate.

Fabbian S, Giachin G, Bellanda M, Borgo C, Ruzzene M, Spuri G, Campofelice A, Veneziano L, Bonchio M, Carraro M, Battistutta R
Front Mol Biosci 9:906390 (2022)
PMID: 35720133
doi: 10.3389/fmolb.2022.906390 		Submitted to SASBDB: 2022 Mar 19
Published in SASBDB:

SASDNF7 – CK2α (Casein kinase II subunit alpha)

Casein kinase II subunit alpha experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Casein kinase II subunit alpha monomer, 39 kDa Homo sapiens protein
Buffer: 25 mM Tris, 500 mM NaCl, pH: 8.5
Experiment: SAXS data collected at BM29, ESRF on 2021 Oct 10
RgGuinier 2.2 nm
Dmax 6.7 nm
VolumePorod 59 nm3

SASDNG7 – CK2α (Casein kinase II subunit alpha) dimer bound to ruthenium-based polyoxometalate (Ru4POM)

Casein kinase II subunit alpha experimental SAS data
CUSTOM IN-HOUSE model
Sample: Casein kinase II subunit alpha dimer, 78 kDa Homo sapiens protein
Buffer: 25 mM Tris, 500 mM NaCl, pH: 8.5
Experiment: SAXS data collected at BM29, ESRF on 2021 Oct 10
RgGuinier 3.0 nm
Dmax 11.8 nm
VolumePorod 122 nm3