A tetracationic porphyrin with dual anti-prion activity.

Masone A, Zucchelli C, Caruso E, Lavigna G, Eraña H, Giachin G, Tapella L, Comerio L, Restelli E, Raimondi I, Elezgarai SR, De Leo F, Quilici G, Taiarol L, Oldrati M, Lorenzo NL, García-Martínez S, Cagnotto A, Lucchetti J, Gobbi M, Vanni I, Nonno R, Di Bari MA, Tully MD, Cecatiello V, Ciossani G, Pasqualato S, Van Anken E, Salmona M, Castilla J, Requena JR, Banfi S, Musco G, Chiesa R
iScience 26(9):107480 (2023 Sep 15)

PMID: 37636075 doi: 10.1016/j.isci.2023.107480

Submitted to SASBDB: 2022 Apr 6 Published in SASBDB: 2023 Jun 27

SASDNB8 – Mature full length human prion protein Sample: Major prion protein monomer, 23 kDa Homo sapiens protein Buffer: 10 mM HEPES 100 mM NaCl, pH: 7 Experiment: SAXS data collected at BM29, ESRF on 2020 Dec 13 RgGuinier 2.8 nm Dmax 10.2 nm

SASDNC8 – Mature full length human prion protein in the presence of zinc-tetracationic porphyrin [Zn(II)-BnPyP] Sample: Major prion protein monomer, 23 kDa Homo sapiens protein Buffer: 10 mM HEPES 100 mM NaCl, pH: 7 Experiment: SAXS data collected at BM29, ESRF on 2020 Dec 13 RgGuinier 3.1 nm Dmax 11.3 nm

SASDND8 – Mature full length human prion protein in the presence of a cationic Fe(III) porphyrin [Fe(III)-TMPyP] Sample: Major prion protein monomer, 23 kDa Homo sapiens protein Buffer: 10 mM HEPES 100 mM NaCl, pH: 7 Experiment: SAXS data collected at BM29, ESRF on 2020 Dec 13 RgGuinier 2.8 nm Dmax 10.3 nm