Time-resolved small-angle X-ray scattering study of polymorphic nature of Aß42 oligomerisation

Tia Cheremnykh

Submitted to SASBDB: 2022 Aug 9 Published in SASBDB: 2024 May 16

SASDPP7 – Amyloid Beta 1-42 (cluster 1, Set 2, final state) Sample: Amyloid-beta precursor protein, 5 kDa Homo sapiens protein Buffer: 1 mM Hepes, 0.12 % NH4OH, pH: 10.7 Experiment: SAXS data collected at EMBL P12, PETRA III on 2019 Apr 11 RgGuinier 5.8 nm Dmax 42.0 nm

SASDPQ7 – Amyloid Beta 1-42 (cluster 1, Set 3, final state) Sample: Amyloid-beta precursor protein, 5 kDa Homo sapiens protein Buffer: 1 mM Hepes, 0.12 % NH4OH, pH: 10.7 Experiment: SAXS data collected at EMBL P12, PETRA III on 2019 Dec 13 RgGuinier 6.9 nm Dmax 60.0 nm

SASDPR7 – Amyloid Beta 1-42 (cluster 2, Set 4, initial state) Sample: Amyloid-beta precursor protein, 5 kDa Homo sapiens protein Buffer: 1 mM Hepes, 0.1 % NH4OH (pH∼10.7), pH: 10.7 Experiment: SAXS data collected at EMBL P12, PETRA III on 2020 Oct 31 RgGuinier 2.5 nm Dmax 6.5 nm

SASDPS7 – Amyloid Beta 1-42 (cluster 2, Set 4, final state) Sample: Amyloid-beta precursor protein, 5 kDa Homo sapiens protein Buffer: 1 mM Hepes, 0.1 % NH4OH (pH∼10.7), pH: 10.7 Experiment: SAXS data collected at EMBL P12, PETRA III on 2020 Nov 1 RgGuinier 3.7 nm Dmax 9.1 nm

SASDPT7 – Amyloid Beta 1-42 (cluster 2, Set 5, final state) Sample: Amyloid-beta precursor protein, 5 kDa Homo sapiens protein Buffer: 1 mM Hepes, 0.1 % NH4OH (pH∼10.7), pH: 10.7 Experiment: SAXS data collected at EMBL P12, PETRA III on 2020 Nov 1 RgGuinier 3.7 nm Dmax 11.0 nm

SASDPU7 – Amyloid Beta 1-42 (cluster 1, Set 1, initial state) Sample: Amyloid-beta precursor protein, 5 kDa Homo sapiens protein Buffer: 1 mM Hepes, 0.12 % NH4OH, pH: 10.7 Experiment: SAXS data collected at EMBL P12, PETRA III on 2018 Nov 2 RgGuinier 3.5 nm Dmax 15.0 nm