Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity.

Sun Y, Yang XN, Yang SS, Lyu YZ, Zhang B, Liu KW, Li N, Cui JC, Huang GX, Liu CL, Xu J, Mi JQ, Chen Z, Fan XH, Chen SJ, Chen S
Signal Transduct Target Ther 8(1):445 (2023 Dec 8)

PMID: 38062078 doi: 10.1038/s41392-023-01686-z

Submitted to SASBDB: 2023 Jan 9 Published in SASBDB: 2023 Dec 15

SASDQV9 – Nanobody1 in complex with the extracellular domain of human BCMA Sample: Tumor necrosis factor receptor superfamily member 17 monomer, 6 kDa Homo sapiens protein Nanobody1 monomer, 14 kDa protein Buffer: 20 mM Tris, 100 mM NaCl, pH: 8 Experiment: SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2022 Aug 28 RgGuinier 3.0 nm Dmax 9.8 nm VolumePorod 52 nm3

SASDQW9 – Nanobody2 in complex with the extracellular domain of human BCMA Sample: Tumor necrosis factor receptor superfamily member 17 monomer, 6 kDa Homo sapiens protein Nanobody2 monomer, 14 kDa protein Buffer: 20 mM Tris, 100 mM NaCl, pH: 8 Experiment: SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2022 Aug 28 RgGuinier 2.0 nm Dmax 9.0 nm VolumePorod 24 nm3

SASDQX9 – Tandem nanobody in complex with the extracellular domain of human BCMA Sample: Tumor necrosis factor receptor superfamily member 17 monomer, 6 kDa Homo sapiens protein Tandem nanobody monomer, 27 kDa protein Buffer: 20 mM Tris, 100 mM NaCl, pH: 8 Experiment: SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2022 Aug 28 RgGuinier 5.1 nm Dmax 23.3 nm VolumePorod 247 nm3