Homomeric interactions of the MPZ Ig domain and their relation to Charcot-Marie-Tooth disease

Ptak C, Peterson T, Hopkins J, Ahern C, Shy M, Piper R
Brain (2023 Aug 05)

doi: 10.1093/brain/awad258
Submitted to SASBDB: 2023 Jan 17
Published in SASBDB:

SASDRC3 – Homo-oligomeric mixture of human myelin protein zero Ig domain

Myelin protein P0 experimental SAS data
ALPHAFOLD model
Sample: Myelin protein P0, 15 kDa Homo sapiens protein
Buffer: 50 mM NaCl, 1 mM EDTA, 20 mM TrisCl, pH: 7.6
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2021 Jul 21
RgGuinier 2.9 nm
Dmax 17.0 nm

SASDRD3 – Homo-oligomeric mixture of human myelin protein zero Ig domain (W53A, R74A, D75R mutant)

Myelin protein P0 (W53A, R74A, D75R) experimental SAS data
ALPHAFOLD model
Sample: Myelin protein P0 (W53A, R74A, D75R), 14 kDa Homo sapiens protein
Buffer: 50 mM NaCl, 1 mM EDTA, 20 mM TrisCl, pH: 7.6
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Jul 14
RgGuinier 1.9 nm
Dmax 7.0 nm