Extrinsic stabilization of antiviral ACE2-Fc fusion proteins targeting SARS-CoV-2.

Svilenov HL, Delhommel F, Siebenmorgen T, Rührnößl F, Popowicz GM, Reiter A, Sattler M, Brockmeyer C, Buchner J
Commun Biol 6(1):386 (2023 Apr 8)

PMID: 37031320 doi: 10.1038/s42003-023-04762-w

Submitted to SASBDB: 2023 Mar 13 Published in SASBDB: 2023 Apr 11

SASDRU7 – Angiotensin-converting enzyme 2/immunoglobulin-Fc chimera protein (Ace2-Fc) at 3.81 mg/ml Sample: Angiotensin-converting enzyme 2 chimera with the Fc region of the immunoglobulin heavy constant gamma 4 dimer, 217 kDa Homo sapiens protein Buffer: 50 mM Tris, 150 mM NaCl, pH: 7.5 Experiment: SAXS data collected at Rigaku BioSAXS-1000, SFB 1035, Technische Universität München on 2021 Jul 5 RgGuinier 5.5 nm Dmax 18.6 nm VolumePorod 408 nm3