1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterisation and biological evaluation of inhibitors

Mazzone F, Hoeppner A, Reiners J, Gertzen C, Applegate V, Abdullaziz M, Gottstein J, Degrandi D, Wesemann M, Kurz T, Smits S, Pfeffer K
Biochemical Journal (2024 Aug 06)

doi: 10.1042/BCJ20240110 		Submitted to SASBDB: 2023 Jul 5
Published in SASBDB:

SASDS47 – 1-Deoxy-D-xylulose-5-phosphate reductoisomerase (DXR)

1-deoxy-D-xylulose-5-phosphate reductoisomerase (G328C, K361E, S551G) experimental SAS data
1-Deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) Rg histogram
Sample: 1-deoxy-D-xylulose-5-phosphate reductoisomerase (G328C, K361E, S551G) dimer, 104 kDa Toxoplasma gondii (strain … protein
Buffer: 20 mM Tris/HCl, 150 mM NaCl, 40 mM MgCl2, 2% glycerol,, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2023 Apr 25
RgGuinier 3.3 nm
Dmax 10.4 nm
VolumePorod 176 nm3