Structural properties of the HNF-1A transactivation domain

Kind L, Driver M, Raasakka A, Onck P, Njølstad P, Arnesen T, Kursula P
Frontiers in Molecular Biosciences 10 (2023 Oct 16)

doi: 10.3389/fmolb.2023.1249939 		Submitted to SASBDB: 2023 Aug 30
Published in SASBDB:

SASDSZ8 – The DNA binding domain (DBD) of Hepatocyte nuclear factor 1-alpha (HNF-1A)

Hepatocyte nuclear factor 1-alpha experimental SAS data
Hepatocyte nuclear factor 1-alpha Kratky plot
Sample: Hepatocyte nuclear factor 1-alpha monomer, 23 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 500 mM NaCl, 1 mM TCEP,, pH: 8
Experiment: SAXS data collected at EMBL P12, PETRA III on 2020 Jun 25
RgGuinier 2.7 nm
Dmax 10.2 nm
VolumePorod 22 nm3

SASDS29 – The DNA binding and transactivation domains (DBD-TAD) of Hepatocyte nuclear factor 1-alpha (HNF-1A)

Hepatocyte nuclear factor 1-alpha experimental SAS data
Hepatocyte nuclear factor 1-alpha Kratky plot
Sample: Hepatocyte nuclear factor 1-alpha monomer, 62 kDa Homo sapiens protein
Buffer: 4 mM Tris, 100 mM NaCl, 1 mM TCEP,, pH: 8.5
Experiment: SAXS data collected at CoSAXS, MAX IV on 2022 Apr 2
RgGuinier 4.9 nm
Dmax 17.0 nm
VolumePorod 109 nm3