Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring

Martin Høgholm Jørgensen Submitted to SASBDB: 2024 Jan 9
Published in SASBDB:

SASDTU8 – Complement C3* at 1.25 mg/mL (pH 6.0, 200 mM NaCl)

Complement C3 (Δ668-671) experimental SAS data
CORAL model
Sample: Complement C3 (Δ668-671) monomer, 187 kDa Homo sapiens protein
Buffer: 20 mM MES pH 6.0, 200 mM NaCl, pH: 6
Experiment: SAXS data collected at EMBL P12, PETRA III on 2022 Nov 7
RgGuinier 5.4 nm
Dmax 21.8 nm
VolumePorod 357 nm3