Biophysical analysis of the membrane-proximal Venus Flytrap domain of ESAG4 receptor-like adenylate cyclase from Trypanosoma brucei.

Alves DO, Geens R, da Silva Arruda HR, Jennen L, Corthaut S, Wuyts E, de Andrade GC, Prosdocimi F, Cordeiro Y, Pires JR, Vieira LR, de Oliveira GAP, Sterckx YG, Salmon D
Mol Biochem Parasitol 260:111653 (2024 Dec)
PMID: 39447762
doi: 10.1016/j.molbiopara.2024.111653 		Submitted to SASBDB: 2024 May 10
Published in SASBDB:

SASDU78 – Trypanosoma brucei ESAG4 membrane-proximal Venus Fly Trap domain 2 (VFT2)

adenylate cyclase experimental SAS data
ALPHAFOLD model
Sample: Adenylate cyclase monomer, 43 kDa Trypanosoma brucei protein
Buffer: 50 mM Tris-HCl, 500 mM NaCl, pH: 8
Experiment: SAXS data collected at BM29, ESRF on 2023 Sep 23
RgGuinier 2.3 nm
Dmax 7.6 nm
VolumePorod 76 nm3