Optimization of Structure‐Guided Development of Chemical Probes for the Pseudoknot RNA of the Frameshift Element in SARS‐CoV‐2

Ceylan B, Adam J, Toews S, Kaiser F, Dörr J, Scheppa D, Tants J, Smart A, Schoth J, Philipp S, Stirnal E, Ferner J, Richter C, Sreeramulu S, Caliskan N, Schlundt A, Weigand J, Göbel M, Wacker A, Schwalbe H
Angewandte Chemie International Edition (2025 Feb 05)

doi: 10.1002/anie.202417961

Submitted to SASBDB: 2024 Jun 28 Published in SASBDB: 2025 Feb 6

SASDVZ3 – SARS-CoV2 RNA pseudoknot at 4 mg/mL Sample: SARS-CoV2 RNA pseudoknot monomer, 22 kDa Severe acute respiratory … RNA Buffer: 25 mM potassium phosphate, 50 mM KCl, pH: 6.2 Experiment: SAXS data collected at EMBL P12, PETRA III on 2021 Nov 22 RgGuinier 2.3 nm Dmax 7.9 nm VolumePorod 29 nm3

SASDV24 – SARS-CoV2 RNA pseudoknot at 2 mg/mL Sample: SARS-CoV2 RNA pseudoknot monomer, 22 kDa Severe acute respiratory … RNA Buffer: 25 mM potassium phosphate, 50 mM KCl, pH: 6.2 Experiment: SAXS data collected at EMBL P12, PETRA III on 2021 Nov 22 RgGuinier 2.5 nm Dmax 8.9 nm VolumePorod 32 nm3

SASDV34 – SARS-CoV2 RNA pseudoknot at 1 mg/mL Sample: SARS-CoV2 RNA pseudoknot monomer, 22 kDa Severe acute respiratory … RNA Buffer: 25 mM potassium phosphate, 50 mM KCl, pH: 6.2 Experiment: SAXS data collected at EMBL P12, PETRA III on 2021 Nov 22 RgGuinier 2.5 nm Dmax 9.5 nm VolumePorod 32 nm3