A conformational fingerprint for amyloidogenic light chains

Paissoni C, Puri S, Broggini L, Sriramoju M, Maritan M, Russo R, Speranzini V, Ballabio F, Nuvolone M, Merlini G, Palladini G, Hsu S, Ricagno S, Camilloni C
(2025 Feb 14)

doi: 10.7554/eLife.102002

Submitted to SASBDB: 2024 Jul 12 Published in SASBDB: 2025 Feb 24

SASDVK4 – Immunoglobulin light chain AL55 Sample: Immunoglobulin light chain AL55 dimer, 47 kDa Homo sapiens protein Buffer: 20 mM TrisHCL, 150 mM NaCl, pH: 8 Experiment: SAXS data collected at BM29, ESRF on 2022 Jan 15 RgGuinier 2.6 nm Dmax 8.5 nm VolumePorod 61 nm3

SASDVL4 – Immunoglobulin light chain H3 Sample: Immunoglobulin light chain H3 dimer, 45 kDa Homo sapiens protein Buffer: 20 mM TrisHCL, 150 mM NaCl, pH: 8 Experiment: SAXS data collected at EMBL P12, PETRA III on 2018 May 12 RgGuinier 2.6 nm Dmax 8.4 nm VolumePorod 56 nm3

SASDVM4 – Immunoglobulin light chain H7 Sample: Immunoglobulin light chain H7 dimer, 45 kDa Homo sapiens protein Buffer: 20 mM TrisHCL, 150 mM NaCl, pH: 8 Experiment: SAXS data collected at EMBL P12, PETRA III on 2018 May 12 RgGuinier 2.5 nm Dmax 8.4 nm VolumePorod 54 nm3

SASDVN4 – Immunoglobulin light chain H18 Sample: Immunoglobulin light chain H18 dimer, 43 kDa Homo sapiens protein Buffer: 20 mM TrisHCL, 150 mM NaCl, pH: 8 Experiment: SAXS data collected at BM29, ESRF on 2021 Jul 2 RgGuinier 2.6 nm Dmax 8.2 nm VolumePorod 58 nm3

SASDVP4 – Immunoglobulin light chain M7 Sample: Immunoglobulin light chain M7 dimer, 46 kDa Homo sapiens protein Buffer: 20 mM TrisHCL, 150 mM NaCl, pH: 8 Experiment: SAXS data collected at EMBL P12, PETRA III on 2018 May 12 RgGuinier 2.5 nm Dmax 8.0 nm VolumePorod 58 nm3

SASDVQ4 – Immunoglobulin light chain M10 Sample: Immunoglobulin light chain M10 dimer, 45 kDa Homo sapiens protein Buffer: 20 mM TrisHCL, 150 mM NaCl, pH: 8 Experiment: SAXS data collected at BM29, ESRF on 2023 Mar 17 RgGuinier 2.6 nm Dmax 8.3 nm VolumePorod 58 nm3