Computational study of DPP8 and DPP9: fundamental insights and inhibitor design

Olivier Beyens, Yann Sterckx
University of Antwerp PhD thesis c:irua:209673 (2024 Nov 06)

URL: https://repository.uantwerpen.be/docstore/d:irua:26291

Submitted to SASBDB: 2024 Aug 26 Published in SASBDB: 2025 Jan 14

SASDVJ6 – apo Dipeptidyl peptidase 8 (DPP8 apo) Sample: Isoform 1 of Dipeptidyl peptidase 8 dimer, 208 kDa Homo sapiens protein Buffer: 25 mM HEPES, 150 mM NaCl, 2 mM DTT, pH: 7.5 Experiment: SAXS data collected at SWING, SOLEIL on 2023 Oct 14 RgGuinier 4.2 nm Dmax 13.6 nm VolumePorod 271 nm3

SASDVK6 – Dipeptidyl peptidase 8 (DPP8) with compound 42 Sample: Isoform 1 of Dipeptidyl peptidase 8 dimer, 208 kDa Homo sapiens protein Buffer: 25 mM HEPES, 150 mM NaCl, 2 mM DTT, pH: 7.5 Experiment: SAXS data collected at SWING, SOLEIL on 2023 Oct 14 RgGuinier 4.2 nm Dmax 13.7 nm VolumePorod 277 nm3

SASDVL6 – apo Dipeptidyl peptidase 9 (DPP9 apo) Sample: Isoform 1 of Dipeptidyl peptidase 9 dimer, 198 kDa Homo sapiens protein Buffer: 25 mM HEPES, 150 mM NaCl, 2 mM DTT, pH: 7.5 Experiment: SAXS data collected at BM29, ESRF on 2023 Sep 23 RgGuinier 4.2 nm Dmax 13.3 nm VolumePorod 290 nm3

SASDVM6 – Dipeptidyl peptidase 9 (DPP9) with compound 42 Sample: Isoform 1 of Dipeptidyl peptidase 9 dimer, 198 kDa Homo sapiens protein Buffer: 25 mM HEPES, 150 mM NaCl, 2 mM DTT, pH: 7.5 Experiment: SAXS data collected at BM29, ESRF on 2023 Sep 23 RgGuinier 4.1 nm Dmax 12.5 nm VolumePorod 274 nm3