Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

Lambert JP, Picaud S, Fujisawa T, Hou H, Savitsky P, Uusküla-Reimand L, Gupta GD, Abdouni H, Lin ZY, Tucholska M, Knight JDR, Gonzalez-Badillo B, St-Denis N, Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P, Gingras AC
Mol Cell (2018 Dec 13)

PMID: 30554943 doi: 10.1016/j.molcel.2018.11.006

Submitted to SASBDB: 2017 Apr 12 Published in SASBDB: 2018 Sep 10

SASDCT2 – Bromodomain-containing protein 2 (BRD2) tandem bromodomains Sample: Bromodomain-containing protein 2 monomer, 43 kDa Homo sapiens protein Buffer: 20 mM HEPES, 150 mM NaCl, 2% glycerol, 0.5 mM TCEP, pH: 7.5 Experiment: SAXS data collected at B21, Diamond Light Source on 2017 Jan 13 RgGuinier 5.7 nm Dmax 21.0 nm VolumePorod 220 nm3

SASDCS2 – Bromodomain-containing protein 3 (BRD3) tandem bromodomains Sample: Bromodomain-containing protein 3 monomer, 44 kDa Homo sapiens protein Buffer: 20 mM HEPES, 150 mM NaCl, 2% glycerol, 0.5 mM TCEP, pH: 7.5 Experiment: SAXS data collected at B21, Diamond Light Source on 2017 Jan 13 RgGuinier 6.2 nm Dmax 21.5 nm VolumePorod 210 nm3

SASDCR2 – Bromodomain-containing protein 4 (BRD4) tandem bromodomains Sample: Bromodomain-containing protein 4 monomer, 47 kDa Homo sapiens protein Buffer: 20 mM HEPES, 150 mM NaCl, 2% glycerol, 0.5 mM TCEP, pH: 7.5 Experiment: SAXS data collected at B21, Diamond Light Source on 2017 Jan 13 RgGuinier 6.3 nm Dmax 22.0 nm VolumePorod 251 nm3

SASDCU2 – Bromodomain testis-specific protein (BRDT) tandem bromodomains Sample: Bromodomain testis-specific protein monomer, 43 kDa Homo sapiens protein Buffer: 20 mM HEPES, 150 mM NaCl, 2% glycerol, 0.5 mM TCEP, pH: 7.5 Experiment: SAXS data collected at B21, Diamond Light Source on 2017 Jan 13 RgGuinier 5.1 nm Dmax 20.0 nm VolumePorod 200 nm3