Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil.

Planelles-Herrero VJ, Hartman JJ, Robert-Paganin J, Malik FI, Houdusse A
Nat Commun 8(1):190 (2017 Aug 4)
PMID: 28775348
doi: 10.1038/s41467-017-00176-5 		Submitted to SASBDB: 2017 Jun 7
Published in SASBDB:

SASDCW4 – Bovine β Cardiac Myosin S1 fragment (Myosin-7) MgADP.VO4+OM

Bovine β Cardiac Myosin S1 fragment experimental SAS data
Bovine β Cardiac Myosin S1 fragment Kratky plot
Sample: Bovine β Cardiac Myosin S1 fragment monomer, 117 kDa Bos taurus protein
Buffer: 10 mM HEPES, 50 mM NaCl, 1 mM NaN3, 2.5 mM MgCl2, 2 mM ADP, 1 mM TCEP, pH: 7.5
Experiment: SAXS data collected at SWING, SOLEIL on 2016 Mar 1
RgGuinier 3.6 nm
Dmax 12.6 nm
VolumePorod 162 nm3

SASDCX4 – Bovine β Cardiac Myosin S1 fragment (Myosin-7) MgADP+OM

Bovine β Cardiac Myosin S1 fragment experimental SAS data
Bovine β Cardiac Myosin S1 fragment Kratky plot
Sample: Bovine β Cardiac Myosin S1 fragment monomer, 117 kDa Bos taurus protein
Buffer: 10 mM HEPES, 50 mM NaCl, 1 mM NaN3, 2.5 mM MgCl2, 2 mM ADP, 1 mM TCEP, pH: 7.5
Experiment: SAXS data collected at SWING, SOLEIL on 2016 Mar 1
RgGuinier 4.0 nm
Dmax 11.5 nm
VolumePorod 161 nm3