The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module.

Schmidt CQ, Herbert AP, Mertens HD, Guariento M, Soares DC, Uhrin D, Rowe AJ, Svergun DI, Barlow PN
J Mol Biol 395(1):105-22 (2010 Jan 8)
PMID: 19835885
doi: 10.1016/j.jmb.2009.10.010 		Published in SASBDB:

SASDAY4 – fH1015

Factor H CCP modules 10 to 15 experimental SAS data
DAMMIF model
Sample: Factor H CCP modules 10 to 15 monomer, 41 kDa Homo sapiens protein
Buffer: 50 mM Potassium Phosphate, pH: 7.4
Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2008 Dec 2
RgGuinier 3.0 nm
Dmax 10.4 nm
VolumePorod 68 nm3

SASDAZ4 – fH1114

Factor H CCP modules 11 to 14 experimental SAS data
DAMMIF model
Sample: Factor H CCP modules 11 to 14 monomer, 28 kDa Homo sapiens protein
Buffer: 50 mM Potassium Phosphate, pH: 7.4
Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2008 Dec 2
RgGuinier 3.0 nm
Dmax 10.5 nm
VolumePorod 38 nm3

SASDA25 – fh1213

Factor H CCP modules 12 to 13 experimental SAS data
CRYSOL model
Sample: Factor H CCP modules 12 to 13 monomer, 14 kDa Homo sapiens protein
Buffer: 50 mM Potassium Phosphate, pH: 7.4
Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2008 Dec 2
RgGuinier 2.0 nm
Dmax 7.1 nm
VolumePorod 20 nm3