Human stress-inducible Hsp70 has a high propensity to form ATP-dependent antiparallel dimers that are differentially regulated by co-chaperone binding.

Trcka F, Durech M, Vankova P, Chmelik J, Martinkova V, Hausner J, Kadek A, Marcoux J, Klumpler T, Vojtesek B, Muller P, Man P
Mol Cell Proteomics (2018 Nov 20)

PMID: 30459217 doi: 10.1074/mcp.RA118.001044

Submitted to SASBDB: 2018 May 17 Published in SASBDB: 2018 Nov 30

SASDDN6 – Human stress-inducible heat shock 70 kDa protein 1, Hsp70 (Hspa1a) T204A mutant dimer, in the presence of ATP Sample: Heat shock 70 kDa protein 1 dimer, 147 kDa Homo sapiens protein Buffer: 50mM HEPES, 150mM KCH3COO, 2mM MgCl2, pH: 7.5 Experiment: SAXS data collected at Rigaku BioSAXS-1000, CEITEC on 2018 Feb 20 RgGuinier 4.0 nm Dmax 11.6 nm VolumePorod 248 nm3