Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement.

Berry KN, Brett TJ
Cell Rep 30(4):1141-1151.e3 (2020 Jan 28)

PMID: 31995732 doi: 10.1016/j.celrep.2019.12.059

Submitted to SASBDB: 2019 Dec 12 Published in SASBDB: 2020 Feb 3

SASDH24 – Calcium-Activated Chloride Channel Regulator 1 VWA domain Sample: Calcium-activated chloride channel regulator 1 monomer, 20 kDa Homo sapiens protein Buffer: 20 mM HEPES, 150 mM NaCl, 2% glycerol, pH: 7.4 Experiment: SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2017 Jun 6 RgGuinier 1.8 nm Dmax 6.6 nm

SASDH34 – Calcium-Activated Chloride Channel Regulator 1 CAT-CYS-VWA domain construct Sample: Calcium-activated chloride channel regulator 1 monomer, 52 kDa Homo sapiens protein Buffer: 20 mM HEPES, 150 mM NaCl, 2% glycerol, pH: 7.4 Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2017 Jun 6 RgGuinier 3.4 nm Dmax 13.4 nm