Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex.

Song Y, Dagil L, Fairall L, Robertson N, Wu M, Ragan TJ, Savva CG, Saleh A, Morone N, Kunze MBA, Jamieson AG, Cole PA, Hansen DF, Schwabe JWR
Cell Rep 30(8):2699-2711.e8 (2020 Feb 25)
PMID: 32101746
doi: 10.1016/j.celrep.2020.01.091 		Submitted to SASBDB: 2020 Jan 16
Published in SASBDB:

SASDH45 – Histone Deacetylase 1 (HDAC1) and Lysine-specific Demethylase 1 (LSD1) in the complex with CoREST

Histone deacetylase 1Lysine-specific histone demethylase 1AREST corepressor 1 experimental SAS data
DAMFILT model
Sample: Histone deacetylase 1 monomer, 55 kDa Homo sapiens protein
Lysine-specific histone demethylase 1A monomer, 93 kDa Homo sapiens protein
REST corepressor 1 monomer, 46 kDa Homo sapiens protein
Buffer: 25 mM Tris/Cl, 50 mM potassium acetate and 0.5 mM TCEP, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2015 Jan 23
RgGuinier 6.0 nm
Dmax 15.8 nm
VolumePorod 437 nm3