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7 hits found for Hepatocyte growth factor

SASDMT4 – Complex of Met receptor with InlB

Hepatocyte growth factor receptorInternalin B experimental SAS data
SASREF CV model
Sample: Hepatocyte growth factor receptor monomer, 100 kDa Mus musculus protein
Internalin B monomer, 36 kDa Listeria monocytogenes serotype … protein
Buffer: 25mM Na-phosphate buffer, 150 mM NaCl, 1mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2004 Mar 1
X-ray and Neutron Small-Angle Scattering Analysis of the Complex Formed by the Met Receptor and the Listeria monocytogenes Invasion Protein InlB Journal of Molecular Biology 377(2):489-500 (2008)
Niemann H, Petoukhov M, Härtlein M, Moulin M, Gherardi E, Timmins P, Heinz D, Svergun D
RgGuinier 4.6 nm
Dmax 16.0 nm
VolumePorod 270 nm3

SASDLZ5 – Hepatocyte growth factor/Hepatocyte growth factor receptor (NK1-Met567) complex

Hepatocyte growth factorHepatocyte growth factor receptor experimental SAS data
MONSA model
Sample: Hepatocyte growth factor dimer, 39 kDa Homo sapiens protein
Hepatocyte growth factor receptor dimer, 122 kDa Homo sapiens protein
Buffer: Phosphate-buffered saline containing EDTA, surfactant P20 and 5 M NaCl, pH: 6
Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2007 Jun 26
...Hepatocyte Growth Factor/Scatter Factor as a MET Receptor Antagonist Journal of Molecular Biology 377(3):616-622 (2008)
Youles M, Holmes O, Petoukhov M, Nessen M, Stivala S, Svergun D, Gherardi E
RgGuinier 5.3 nm
Dmax 20.0 nm
VolumePorod 290 nm3

SASDLP7 – ...hepatocyte growth factor/scatter factor in complex with receptor tyrosine kinase MET

Hepatocyte growth factorHepatocyte growth factor receptor experimental SAS data
SASREF model
Sample: Hepatocyte growth factor monomer, 79 kDa Mus musculus protein
Hepatocyte growth factor receptor monomer, 100 kDa Mus musculus protein
Buffer: 50 mM MES, 150 mM NaCl, pH: 6.7
Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2004 Feb 9
...hepatocyte growth factor/scatter factor and MET signalling Proceedings of the National Academy of Sciences 103(11):4046-4051 (2006)
Gherardi E, Sandin S, Petoukhov M, Finch J, Youles M, Ofverstedt L, Miguel R, Blundell T, Vande Woude G, Skoglund U, Svergun D
RgGuinier 6.7 nm
Dmax 20.0 nm
VolumePorod 370 nm3

SASDLQ7 – receptor tyrosine kinase MET

Hepatocyte growth factor receptor experimental SAS data
SASREF model
Sample: Hepatocyte growth factor receptor monomer, 100 kDa Mus musculus protein
Buffer: 50 mM MES, 150 mM NaCl, pH: 6.7
Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2004 Feb 7
...hepatocyte growth factor/scatter factor and MET signalling Proceedings of the National Academy of Sciences 103(11):4046-4051 (2006)
Gherardi E, Sandin S, Petoukhov M, Finch J, Youles M, Ofverstedt L, Miguel R, Blundell T, Vande Woude G, Skoglund U, Svergun D
RgGuinier 4.8 nm
Dmax 16.0 nm
VolumePorod 190 nm3

SASDLM9 – ...hepatocyte growth factor mimic K1K1

minimal hepatocyte growth factor mimic K1K1 experimental SAS data
GASBOR model
Sample: ...hepatocyte growth factor mimic K1K1 monomer, 19 kDa synthetic construct protein
Buffer: 25 mM Tris, 150 mM NaCl, pH: 7.4
Experiment: SAXS data collected at BM29, ESRF on 2016 Nov 3
...hepatocyte growth factor/scatter factor provides a potent MET receptor agonist Life Science Alliance 5(12):e202201424 (2022)
de Nola G, Leclercq B, Mougel A, Taront S, Simonneau C, Forneris F, Adriaenssens E, Drobecq H, Iamele L, Dubuquoy L, Melnyk O, Gherardi E, de Jonge H, Vicogne J
RgGuinier 2.2 nm
Dmax 6.6 nm
VolumePorod 22 nm3

SASDLN9 – Hepatocyte growth factor HGF/SF receptor - fragment MET567

Hepatocyte growth factor receptor experimental SAS data
GASBOR model
Sample: Hepatocyte growth factor receptor monomer, 62 kDa Homo sapiens protein
Buffer: 25 mM Tris, 150 mM NaCl, pH: 7.4
Experiment: SAXS data collected at BM29, ESRF on 2018 Jan 27
...hepatocyte growth factor/scatter factor provides a potent MET receptor agonist Life Science Alliance 5(12):e202201424 (2022)
de Nola G, Leclercq B, Mougel A, Taront S, Simonneau C, Forneris F, Adriaenssens E, Drobecq H, Iamele L, Dubuquoy L, Melnyk O, Gherardi E, de Jonge H, Vicogne J
RgGuinier 3.2 nm
Dmax 11.7 nm
VolumePorod 126 nm3

SASDLP9 – Hepatocyte growth factor HGF/SF receptor - fragment MET567 in complex with the minimal hepatocyte growth factor mimic K1K1

minimal hepatocyte growth factor mimic K1K1Hepatocyte growth factor receptor experimental SAS data
CORAL model
Sample: ...hepatocyte growth factor mimic K1K1 monomer, 19 kDa synthetic construct protein
Hepatocyte growth factor receptor monomer, 62 kDa Homo sapiens protein
Buffer: 25 mM Tris, 150 mM NaCl, pH: 7.4
Experiment: SAXS data collected at BM29, ESRF on 2018 Jan 23
...hepatocyte growth factor/scatter factor provides a potent MET receptor agonist Life Science Alliance 5(12):e202201424 (2022)
de Nola G, Leclercq B, Mougel A, Taront S, Simonneau C, Forneris F, Adriaenssens E, Drobecq H, Iamele L, Dubuquoy L, Melnyk O, Gherardi E, de Jonge H, Vicogne J
RgGuinier 3.7 nm
Dmax 14.3 nm
VolumePorod 136 nm3