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2 hits found for Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 - heavy chain

SASDWP2 – Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4

Human immunoglobulin ChiLob 7/4 - kappa chainHuman immunoglobulin gamma 1 (IgG1) ChiLob 7/4 - heavy chain experimental SAS data
Human immunoglobulin ChiLob 7/4 - kappa chain Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 - heavy chain Kratky plot
Sample: Human immunoglobulin ChiLob 7/4 - kappa chain dimer, 47 kDa Homo sapiens protein
Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 - heavy chain dimer, 99 kDa Homo sapiens protein
Buffer: ...150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Sep 28
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 5.1 nm
Dmax 16.6 nm
VolumePorod 214 nm3

SASDUG8 – Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2

Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2 - heavy chainHuman immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2 - kappa light chain experimental SAS data
Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2 - heavy chain Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2 - kappa light chain Kratky plot
Sample: Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2 - heavy chain dimer, 51 kDa Homo sapiens protein
Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2 - kappa light chain dimer, 47 kDa Homo sapiens protein
Buffer: ...150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on ...12
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 4.6 nm
Dmax 17.4 nm
VolumePorod 133 nm3