4 hits found for Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S

...2 – Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S kappa chain C214S mutant Sample: Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S dimer, 99 kDa Homo sapiens protein Human immunoglobulin SAP1.3 - kappa chain C214S dimer, 48 kDa Homo sapiens protein Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5 Experiment: SAXS data collected at ...29, ESRF on 2024 Sep 28 Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025) Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I RgGuinier 4.9 nm Dmax 15.8 nm VolumePorod 213 nm3

...2 – Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S/C227S mutant Sample: Human immunoglobulin SAP1.3 - kappa chain dimer, 48 kDa Homo sapiens protein Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S/C227S dimer, 99 kDa Homo sapiens protein Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5 Experiment: SAXS data collected at ...29, ESRF on 2024 Sep 28 Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025) Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I RgGuinier 5.0 nm Dmax 15.8 nm VolumePorod 222 nm3

SASDUB8 – Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - heavy chain C226S kappa chain C214S mutant Sample: Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - heavy chain C226S dimer, 52 kDa Homo sapiens protein Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - kappa light chain C214S dimer, 48 kDa Homo sapiens protein Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5 Experiment: SAXS data collected at ...29, ESRF on 2022 Jun 8 Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025) Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I RgGuinier 3.8 nm Dmax 12.9 nm VolumePorod 130 nm3

SASDUD8 – Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - heavy chain C226S/C227S mutant Sample: Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - heavy chain C226S/C227S dimer, 52 kDa Homo sapiens protein Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - kappa light chain dimer, 48 kDa Homo sapiens protein Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5 Experiment: SAXS data collected at ...29, ESRF on 2022 Jun 8 Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025) Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I RgGuinier 4.2 nm Dmax 15.1 nm VolumePorod 140 nm3