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5 hits found for Harder

SASDWF4 – Outer membrane protein MIP from Legionella pneumophila (LpMIP) in complex with inhibitor NJS224

Outer membrane protein MIP(2S)‐2‐{[(2S)‐1‐[(4‐ fluorophenyl)methanesulfonyl]piperidin‐2‐ yl]formamido}‐4‐methyl‐N‐[(pyridin‐3‐ yl)methyl]pentanamide experimental SAS data
SREFLEX model
Sample: Outer membrane protein MIP dimer, 46 kDa Legionella pneumophila subsp. … protein
(2S)‐2‐{[(2S)‐1‐[(4‐ fluorophenyl)methanesulfonyl]piperidin‐2‐ yl]formamido}‐4‐methyl‐N‐[(pyridin‐3‐ yl)methyl]pentanamide monomer, 1 kDa
Buffer: 20 mM Tris, 150 mM NaCl, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2021 Nov 22
Structure and Dynamics of Macrophage Infectivity Potentiator Proteins from Pathogenic Bacteria and Protozoans Bound to Fluorinated Pipecolic Acid Inhibitors. J Med Chem (2025)
...Harder JM, Lohr T, Jamithireddy AK, Dajka M, Goretzki B, Joseph B, Guskov A, Harmer NJ, Holzgrabe U, Hellmich UA
RgGuinier 2.9 nm
Dmax 9.7 nm
VolumePorod 61 nm3

SASDWG4 – Outer membrane protein MIP from Legionella pneumophila (LpMIP) in complex with inhibitor NJS227

Outer membrane protein MIP(2S)‐3‐(4‐fluorophenyl)‐2‐{[(2S)‐1‐[(4‐ fluorophenyl)methanesulfonyl]piperidin‐2‐ yl]formamido}‐N‐[(pyridin‐3‐yl)methyl]propanamide experimental SAS data
SREFLEX model
Sample: Outer membrane protein MIP dimer, 46 kDa Legionella pneumophila subsp. … protein
(2S)‐3‐(4‐fluorophenyl)‐2‐{[(2S)‐1‐[(4‐ fluorophenyl)methanesulfonyl]piperidin‐2‐ yl]formamido}‐N‐[(pyridin‐3‐yl)methyl]propanamide monomer, 1 kDa
Buffer: 20 mM Tris, 150 mM NaCl, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2021 Nov 22
Structure and Dynamics of Macrophage Infectivity Potentiator Proteins from Pathogenic Bacteria and Protozoans Bound to Fluorinated Pipecolic Acid Inhibitors. J Med Chem (2025)
...Harder JM, Lohr T, Jamithireddy AK, Dajka M, Goretzki B, Joseph B, Guskov A, Harmer NJ, Holzgrabe U, Hellmich UA
RgGuinier 3.0 nm
Dmax 10.0 nm
VolumePorod 65 nm3

SASDSY6 – Outer membrane protein MIP (LpMIP) apo state

Outer membrane protein MIP experimental SAS data
SREFLEX model
Sample: Outer membrane protein MIP dimer, 46 kDa Legionella pneumophila subsp. … protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 10 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2021 Mar 16
Legionella pneumophila macrophage infectivity potentiator protein appendage domains modulate protein dynamics and inhibitor binding International Journal of Biological Macromolecules :126366 (2023)
...Harder J, Krajczy P, Joseph B, Hausch F, Guskov A, Hellmich U
RgGuinier 3.1 nm
Dmax 10.0 nm
VolumePorod 66 nm3

SASDSZ6 – Outer membrane protein MIP (LpMIP) with bound inhibitor JK095

Outer membrane protein MIP experimental SAS data
SREFLEX model
Sample: Outer membrane protein MIP dimer, 46 kDa Legionella pneumophila subsp. … protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 10 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2021 Mar 16
Legionella pneumophila macrophage infectivity potentiator protein appendage domains modulate protein dynamics and inhibitor binding International Journal of Biological Macromolecules :126366 (2023)
...Harder J, Krajczy P, Joseph B, Hausch F, Guskov A, Hellmich U
RgGuinier 3.1 nm
Dmax 10.2 nm
VolumePorod 65 nm3

SASDS27 – Outer membrane protein MIP (LpMIP) with bound inhibitor JK236

Outer membrane protein MIP experimental SAS data
SREFLEX model
Sample: Outer membrane protein MIP dimer, 46 kDa Legionella pneumophila subsp. … protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 10 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2021 Mar 16
Legionella pneumophila macrophage infectivity potentiator protein appendage domains modulate protein dynamics and inhibitor binding International Journal of Biological Macromolecules :126366 (2023)
...Harder J, Krajczy P, Joseph B, Hausch F, Guskov A, Hellmich U
RgGuinier 3.1 nm
Dmax 9.4 nm
VolumePorod 63 nm3