3 hits found for Human derived autoantibody mAb2G7 heavy chain, mAb2G7 VH

SASDR32 – Human derived autoantibody mAb2G7 at pH 8.0 Sample: Human derived autoantibody mAb2G7 heavy chain, mAb2G7 VH dimer, 103 kDa protein Human derived autoantibody mAb2G7 light chain, mAb2G7 VL dimer, 51 kDa protein Buffer: phosphate buffered saline, pH: 8 Experiment: SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2022 Dec 8 Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis. Nat Struct Mol Biol (2024) Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S RgGuinier 5.0 nm Dmax 16.0 nm VolumePorod 260 nm3

SASDR42 – Human derived autoantibody mAb5F6 at pH 8.0 Sample: Human derived autoantibody mAb2G7 heavy chain, mAb2G7 VH dimer, 103 kDa protein Human derived autoantibody mAb2G7 light chain, mAb2G7 VL dimer, 51 kDa protein Buffer: phosphate buffered saline, pH: 8 Experiment: SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2022 Dec 8 Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis. Nat Struct Mol Biol (2024) Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S RgGuinier 5.0 nm Dmax 15.8 nm VolumePorod 252 nm3

SASDR62 – Human GluN1-GluN2A NMDA receptor in complex with human derived autoantibody mAb2G7 at pH 8.0 Sample: Glutamate receptor ionotropic, NMDA 1 dimer, 193 kDa Homo sapiens protein Glutamate receptor ionotropic, NMDA 2A dimer, 191 kDa Homo sapiens protein Human derived autoantibody mAb2G7 heavy chain, mAb2G7 VH dimer, 103 kDa protein Human derived autoantibody mAb2G7 light chain, mAb2G7 VL dimer, 51 kDa protein Buffer: 150 mM NaCl, 0.1% digitonin, 5 µM Cholesteryl Hemisuccinate TRIS Salt, 0.1 mM CHAPSO, 50 µM EDTA,1 mM Gly/Glu, 20 mM HEPES, pH: 8 Experiment: SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2022 Dec 8 Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis. Nat Struct Mol Biol (2024) Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S RgGuinier 7.7 nm Dmax 25.4 nm VolumePorod 1260 nm3