3 hits found for Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S/C225S

...2 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S/C225S mutant Sample: Human immunoglobulin ChiLob 7/4 - kappa chain dimer, 47 kDa Homo sapiens protein Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S/C225S dimer, 99 kDa Homo sapiens protein Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5 Experiment: SAXS data collected at ...29, ESRF on 2024 Nov 29 Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025) Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I RgGuinier 5.0 nm Dmax 16.5 nm VolumePorod 215 nm3

SASDLG4 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab)2 - Heavy chain C224S+C225S mutant Sample: ChiLob 7/4 IgG2 F(ab)2 C224S/C225S mutant monomer, 99 kDa protein Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5 Experiment: SAXS data collected at ...29, ESRF on 2018 Feb 9 ...human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility Science Immunology 7(73) (2022) Orr C, Fisher H, Yu X, Chan C, Gao Y, Duriez P, Booth S, Elliott I, Inzhelevskaya T, Mockridge I, Penfold C, Wagner A, Glennie M, White A, Essex J, Pearson A, Cragg M, Tews I RgGuinier 4.2 nm Dmax 15.1 nm VolumePorod 135 nm3

SASDUJ8 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C224S/C225S mutant Sample: Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C224S/C225S dimer, 52 kDa Homo sapiens protein Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain dimer, 47 kDa Homo sapiens protein Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5 Experiment: SAXS data collected at ...29, ESRF on 2022 Apr 12 Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025) Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I RgGuinier 4.2 nm Dmax 14.8 nm VolumePorod 127 nm3