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5 hits found for Tyrosine-protein kinase BTK

SASDC52 – ...kinase

Tyrosine-protein kinase BTK (R28C mutant) experimental SAS data
GASBOR model
Sample: Tyrosine-protein kinase BTK (R28C mutant) monomer, 76 kDa Homo sapiens protein
Buffer: 20 mM HEPES 200 mM NaCl, 2 mM DTT and 1 mM MgCl2, pH: 7.5
Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2002 Apr 2
...kinase (Btk) from synchrotron X-ray solution scattering. EMBO J 22(18):4616-24 (2003)
Márquez JA, Smith CI, Petoukhov MV, Lo Surdo P, Mattsson PT, Knekt M, Westlund A, Scheffzek K, Saraste M, Svergun DI
RgGuinier 5.0 nm
Dmax 20.0 nm
VolumePorod 130 nm3

SASDRB9 – ...Kinase - full-length

Tyrosine-protein kinase BTK experimental SAS data
DAMMIF model
Sample: Tyrosine-protein kinase BTK monomer, 77 kDa Mus musculus protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, 2% v/v glycerol, pH: 8
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2019 Dec 9
...BTK PHTH domain drives multiple regulatory states. Elife 12 (2024)
Lin DY, Kueffer LE, Juneja P, Wales TE, Engen JR, Andreotti AH
RgGuinier 4.1 nm
Dmax 19.1 nm
VolumePorod 118 nm3

SASDRC9 – ...Kinase - full-length with A384P, S386P, T387P, A388P and L390F mutations

Tyrosine-protein kinase BTK (A384P, S386P, T387P, A388P, L390F) experimental SAS data
DAMMIF model
Sample: Tyrosine-protein kinase BTK (A384P, S386P, T387P, A388P, L390F) monomer, 77 kDa Mus musculus protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, 2% v/v glycerol, pH: 8
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2019 Dec 9
...BTK PHTH domain drives multiple regulatory states. Elife 12 (2024)
Lin DY, Kueffer LE, Juneja P, Wales TE, Engen JR, Andreotti AH
RgGuinier 3.9 nm
Dmax 15.2 nm
VolumePorod 107 nm3

SASDRD9 – ...Kinase - SH3-SH2-kinase domain

Tyrosine-protein kinase BTK (SH3-SH2-kinase domains) experimental SAS data
DAMMIF model
Sample: Tyrosine-protein kinase BTK (SH3-SH2-kinase domains) monomer, 52 kDa Mus musculus protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, 2% v/v glycerol, pH: 8
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2019 Dec 9
...BTK PHTH domain drives multiple regulatory states. Elife 12 (2024)
Lin DY, Kueffer LE, Juneja P, Wales TE, Engen JR, Andreotti AH
RgGuinier 2.4 nm
Dmax 7.5 nm
VolumePorod 68 nm3

SASDRE9 – ...Kinase - SH3-SH2-kinase domain with A384P, S386P, T387P, A388P and L390F mutations

Tyrosine-protein kinase BTK (SH3-SH2-kinase domain A384P, S386P, T387P, A388P, L390F) experimental SAS data
DAMMIF model
Sample: Tyrosine-protein kinase BTK (SH3-SH2-kinase domain A384P, S386P, T387P, A388P, L390F) monomer, 53 kDa Mus musculus protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, 2% v/v glycerol, pH: 8
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2019 Dec 9
...BTK PHTH domain drives multiple regulatory states. Elife 12 (2024)
Lin DY, Kueffer LE, Juneja P, Wales TE, Engen JR, Andreotti AH
RgGuinier 2.5 nm
Dmax 7.8 nm
VolumePorod 71 nm3