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Sample: |
E3 ubiquitin/ISG15 ligase TRIM25 dimer, 100 kDa Homo sapiens protein
pre-let-7-a-1@1 monomer, 9 kDa synthetic construct RNA
|
Buffer: |
20 mM MES, 75 mM NaCl, 1 mM TCEP, pH: 6.5
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Experiment: |
SAXS
data collected at EMBL P12, PETRA III on 2019 May 14
|
The molecular dissection of TRIM25's RNA-binding mechanism provides key insights into its antiviral activity.
Nat Commun 15(1):8485 (2024)
Álvarez L, Haubrich K, Iselin L, Gillioz L, Ruscica V, Lapouge K, Augsten S, Huppertz I, Choudhury NR, Simon B, Masiewicz P, Lethier M, Cusack S, Rittinger K, Gabel F, Leitner A, Michlewski G, Hentze ...
|
RgGuinier |
5.7 |
nm |
Dmax |
19.8 |
nm |
|