Small Angle Scattering Biological Data Bank SASBDB

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45 hits found for transglutaminase 2

SASDTL3 – ...Transglutaminase: Equilibrium

Protein-glutamine gamma-glutamyltransferase 2 experimental SAS data

Protein-glutamine gamma-glutamyltransferase 2 Kratky plot

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	4.2	nm
D_max	20.0	nm
Volume^Porod	148	nm³

SASDTM3 – ...Transglutaminase + 25 µM GTP

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	3.8	nm
D_max	17.5	nm
Volume^Porod	132	nm³

SASDTN3 – ...Transglutaminase + 50 µM GTP

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	3.7	nm
D_max	17.5	nm
Volume^Porod	124	nm³

SASDTP3 – ...Transglutaminase + 100 µM GTP

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	3.6	nm
D_max	18.0	nm
Volume^Porod	121	nm³

SASDTQ3 – ...Transglutaminase + 250 µM GTP

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	3.5	nm
D_max	17.5	nm
Volume^Porod	120	nm³

SASDNR3 – Fibrillin-1 fragment PF3

Sample:	Fibrillin-1 PF3 monomer, 78 kDa Homo sapiens protein
Buffer:	Tris buffered saline, pH: 7.4
Experiment:	SAXS data collected at ...29, ESRF on 2016 Dec 12

...transglutaminase cross-linked to fibrillin to facilitate TGFβ activation. Matrix Biol (2022)
Lockhart-Cairns MP, Cain SA, Dajani R, Steer R, Thomson J, Alanazi YF, Kielty CM, Baldock C

R_g^Guinier	5.4	nm
D_max	24.0	nm
Volume^Porod	141	nm³

SASDTR3 – ...Transglutaminase + 500 µM GTP

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	3.4	nm
D_max	18.0	nm
Volume^Porod	118	nm³

SASDNS3 – Latent-transforming growth factor beta-binding protein 1 C-terminus

Latent-transforming growth factor beta-binding protein 1 experimental SAS data

Sample:	Latent-transforming growth factor beta-binding protein 1 monomer, 44 kDa Homo sapiens protein
Buffer:	Tris buffered saline, pH: 7.4
Experiment:	SAXS data collected at ...29, ESRF on 2016 Dec 12

...transglutaminase cross-linked to fibrillin to facilitate TGFβ activation. Matrix Biol (2022)
Lockhart-Cairns MP, Cain SA, Dajani R, Steer R, Thomson J, Alanazi YF, Kielty CM, Baldock C

R_g^Guinier	4.7	nm
D_max	20.5	nm
Volume^Porod	102	nm³

SASDTS3 – ...Transglutaminase + 1 mM GTP

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	3.4	nm
D_max	17.0	nm
Volume^Porod	115	nm³

SASDNT3 – ...transglutaminase 2

Latent-transforming growth factor beta-binding protein 1Fibrillin-1 PF3 experimental SAS data

Sample:	Latent-transforming growth factor beta-binding protein 1 monomer, 44 kDa Homo sapiens protein Fibrillin-1 PF3 monomer, 78 kDa Homo sapiens protein
Buffer:	10 mM Hepes, 150 mM NaCl, pH: 7.4
Experiment:	SAXS data collected at ...29, ESRF on 2017 Jul 20

...transglutaminase cross-linked to fibrillin to facilitate TGFβ activation. Matrix Biol (2022)
Lockhart-Cairns MP, Cain SA, Dajani R, Steer R, Thomson J, Alanazi YF, Kielty CM, Baldock C

R_g^Guinier	7.4	nm
D_max	29.6	nm
Volume^Porod	759	nm³

SASDTT3 – ...Transglutaminase + 2 mM GTP

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	3.3	nm
D_max	17.0	nm
Volume^Porod	111	nm³

SASDTU3 – ...Transglutaminase + 5 mM GTP: Equilibrium

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, 5 mM GTP, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	3.2	nm
D_max	14.0	nm
Volume^Porod	108	nm³

SASDTV3 – ...Transglutaminase + 5 mM GDP

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	3.5	nm
D_max	17.5	nm
Volume^Porod	120	nm³

SASDNW3 – ...2 crosslinked to tropoelastin by transglutaminase 2

Fibrillin-1Elastin experimental SAS data

Sample:	Fibrillin-1 monomer, 44 kDa Homo sapiens protein Elastin monomer, 60 kDa Homo sapiens protein
Buffer:	Tris buffered saline, pH: 7.4
Experiment:	SAXS data collected at ...21, Diamond Light Source on 2018 Feb 21

Transglutaminase-Mediated Cross-Linking of Tropoelastin to Fibrillin Stabilises the Elastin Precursor Prior to Elastic Fibre Assembly. J Mol Biol 432(21):5736-5751 (2020)
Lockhart-Cairns MP, Newandee H, Thomson J, Weiss AS, Baldock C, Tarakanova A

R_g^Guinier	7.1	nm
D_max	23.5	nm

SASDTW3 – ...Transglutaminase + 250 µM CaCl2

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	4.3	nm
D_max	21.0	nm
Volume^Porod	160	nm³

SASDTX3 – ...Transglutaminase + 500 µM CaCl2

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	4.3	nm
D_max	20.0	nm
Volume^Porod	158	nm³

SASDTY3 – ...Transglutaminase + 1 mM CaCl2

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	4.5	nm
D_max	24.0	nm
Volume^Porod	180	nm³

SASDTZ3 – ...Transglutaminase + 2 mM CaCl2

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	5.3	nm
D_max	25.5	nm
Volume^Porod	234	nm³

...24 – ...Transglutaminase + 50 µM inhibitor LM11

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	4.3	nm
D_max	20.0	nm
Volume^Porod	158	nm³

SASDT34 – ...Transglutaminase + 50 µM inhibitor LM11 + 250 µM CaCl2

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	4.2	nm
D_max	19.0	nm
Volume^Porod	155	nm³

SASDT44 – ...Transglutaminase + 50 µM inhibitor LM11 + 500 µM CaCl2

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	4.9	nm
D_max	25.0	nm
Volume^Porod	191	nm³

SASDT54 – ...Transglutaminase + 50 µM inhibitor LM11 + 1 mM CaCl2

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	4.7	nm
D_max	28.0	nm
Volume^Porod	198	nm³

SASDT64 – ...Transglutaminase + 50 µM inhibitor LM11 + 2 mM CaCl2

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	5.2	nm
D_max	25.0	nm
Volume^Porod	236	nm³

SASDT74 – ...Transglutaminase + CaCl2 + inhibitor LM11: Equilibrium

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, 2 mM CaCl2, 50 µM LM11, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	6.0	nm
D_max	36.0	nm
Volume^Porod	431	nm³

SASDT84 – ...Transglutaminase + inhibitor LM11 + CaCl2: Time-resolved 100 ms

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	4.6	nm
D_max	32.0	nm
Volume^Porod	242	nm³

SASDT94 – ...Transglutaminase + inhibitor LM11 + CaCl2: Time-resolved 316 ms

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	4.8	nm
D_max	25.0	nm
Volume^Porod	203	nm³

SASDTA4 – ...Transglutaminase + inhibitor LM11 + CaCl2: Time-resolved 631 ms

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	5.7	nm
D_max	33.0	nm
Volume^Porod	305	nm³

SASDTB4 – ...Transglutaminase + CaCl2 + inhibitor LM11 + GTP: Equilibrium

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, 2 mM CaCl2, 50 µM LM11, 5 mM GTP, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	6.2	nm
D_max	33.0	nm
Volume^Porod	277	nm³

SASDTC4 – ...Transglutaminase + 50 µM inhibitor 5826 (1% DMSO)

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	4.1	nm
D_max	19.0	nm
Volume^Porod	144	nm³

SASDTD4 – ...Transglutaminase + 50 µM inhibitor 5826 (2% DMSO)

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	3.9	nm
D_max	18.5	nm
Volume^Porod	134	nm³

SASDTE4 – ...Transglutaminase + 100 µM inhibitor 5826 (2% DMSO)

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	3.8	nm
D_max	17.6	nm
Volume^Porod	130	nm³

SASDTF4 – ...Transglutaminase + CaCl2 + inhibitor 5826: Equilibrium

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, 2 mM CaCl2, 50 µM 5826 inhibitor, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	6.7	nm
D_max	39.0	nm
Volume^Porod	450	nm³

SASDTG4 – ...Transglutaminase + CaCl2 + inhibitor 5826 + GTP: Equilibrium

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, 2 mM CaCl2, 50 µM 5826, 5 mM GTP, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	6.0	nm
D_max	29.0	nm
Volume^Porod	248	nm³

SASDTH4 – ...Transglutaminase + 1% DMSO

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	4.0	nm
D_max	18.5	nm
Volume^Porod	139	nm³

SASDTJ4 – ...Transglutaminase + 2% DMSO

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	3.9	nm
D_max	18.5	nm
Volume^Porod	133	nm³

SASDTK4 – ...Transglutaminase + 5% DMSO

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	3.9	nm
D_max	18.5	nm
Volume^Porod	133	nm³

SASDTL4 – ...Transglutaminase + 10% DMSO

Sample:	...2 , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	4.1	nm
D_max	21.5	nm
Volume^Porod	148	nm³

SASDTM4 – ...Transglutaminase R580K mutant

Protein-glutamine gamma-glutamyltransferase 2 (R580K) experimental SAS data

Protein-glutamine gamma-glutamyltransferase 2 (R580K) Kratky plot

Sample:	...2 (R580K) , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	6.1	nm
D_max	32.0	nm
Volume^Porod	488	nm³

SASDTN4 – ...Transglutaminase R580K mutant + 100 µM GTP

Sample:	...2 (R580K) , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	5.9	nm
D_max	27.0	nm
Volume^Porod	381	nm³

SASDTP4 – ...Transglutaminase R580K mutant + 1 mM GTP

Sample:	...2 (R580K) , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	5.7	nm
D_max	30.0	nm
Volume^Porod	283	nm³

SASDTQ4 – ...Transglutaminase R580K mutant + 2 mM GTP

Sample:	...2 (R580K) , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	5.3	nm
D_max	25.0	nm
Volume^Porod	264	nm³

SASDTR4 – ...Transglutaminase R580K mutant + 5 mM GTP

Sample:	...2 (R580K) , 77 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 10% glycerol, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2022 Nov 17

...transglutaminase 2 to promote cancer cell survival versus cell death. Commun Biol 7(1):982 (2024)
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK

R_g^Guinier	5.2	nm
D_max	25.0	nm
Volume^Porod	243	nm³

...28 – ...2 antibody (679 14 E06)

anti-TG2 antibody (679 14 E06) experimental SAS data

Sample:	...2 antibody (679 14 E06) monomer, 48 kDa protein
Buffer:	20 mM Tris 150mM NaCl 1mM EDTA, pH: 7.2
Experiment:	SAXS data collected at ...2, PETRA III on 2015 Jan 17

...Transglutaminase 2-specific Autoantibodies in Celiac Disease. J Biol Chem 290(35):21365-75 (2015)
Chen X, Hnida K, Graewert MA, Andersen JT, Iversen R, Tuukkanen A, Svergun D, Sollid LM

R_g^Guinier	2.5	nm
D_max	8.1	nm
Volume^Porod	58	nm³

SASDA38 – transglutaminase-2 (TGA2)

transglutaminase 2 experimental SAS data

Sample:	transglutaminase 2 monomer, 79 kDa Homo sapiens protein
Buffer:	20 mM Tris 150mM NaCl 1mM EDTA, pH: 7.2
Experiment:	SAXS data collected at ...2, PETRA III on 2015 Jan 17

...Transglutaminase 2-specific Autoantibodies in Celiac Disease. J Biol Chem 290(35):21365-75 (2015)
Chen X, Hnida K, Graewert MA, Andersen JT, Iversen R, Tuukkanen A, Svergun D, Sollid LM

R_g^Guinier	3.4	nm
D_max	12.0	nm
Volume^Porod	117	nm³

SASDA48 – transglutaminase2:anti-transglutaminase2 FAB1 antibody complex

anti-TG2 antibody (679 14 E06) transglutaminase 2 experimental SAS data

Sample:	...2 antibody (679 14 E06) monomer, 48 kDa protein transglutaminase 2 monomer, 79 kDa Homo sapiens protein
Buffer:	20 mM Tris 150mM NaCl 1mM EDTA, pH: 7.2
Experiment:	SAXS data collected at ...2, PETRA III on 2015 Jan 17

...Transglutaminase 2-specific Autoantibodies in Celiac Disease. J Biol Chem 290(35):21365-75 (2015)
Chen X, Hnida K, Graewert MA, Andersen JT, Iversen R, Tuukkanen A, Svergun D, Sollid LM

R_g^Guinier	4.0	nm
D_max	13.9	nm
Volume^Porod	168	nm³