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8 hits found for Bradshaw

SASDDP6 – Anti-CD32b Antibody Clone 6G08 Antibody Binding Fragment (6G08 F(ab))

Anti-CD32b Antibody Clone 6G08 Antibody Binding Fragment experimental SAS data
Anti-CD32b Antibody Clone 6G08 Antibody Binding Fragment Kratky plot
Sample: Anti-CD32b Antibody Clone 6G08 Antibody Binding Fragment monomer, 46 kDa Homo sapiens protein
Buffer: 50mM HEPES, 150mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2014 Dec 5
Evaluating Anti-CD32b F(ab) Conformation Using Molecular Dynamics and Small-Angle X-Ray Scattering. Biophys J 115(2):289-299 (2018)
...Bradshaw RT, Orr CM, Frendéus B, Larsson G, Teige I, Cragg MS, Tews I, Essex JW
RgGuinier 2.6 nm
Dmax 7.3 nm
VolumePorod 68 nm3

SASDDK7 – Disrupted-in-Schizophrenia 1 protein (DISC1 12d2)

Disrupted- in-schizophrenia 1 (DISC1 12D2) 691-836 experimental SAS data
GASBOR model
Sample: Disrupted- in-schizophrenia 1 (DISC1 12D2) 691-836 monomer, 19 kDa protein
Buffer: 25 mM Tris-HCl, 150 mM NaCl, 1mM DTT, pH: 7.4
Experiment: SAXS data collected at EMBL P12, PETRA III on 2015 Oct 1
Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein. PLoS One 13(1):e0191162 (2018)
...Bradshaw NJ, Prikulis I, Willbold D, Weiergräber OH, Korth C
RgGuinier 2.6 nm
Dmax 7.3 nm
VolumePorod 41 nm3

SASDDL7 – anti-DISC1 single-domain camelid antibody VHH B5

anti-DISC1 single-domain camelid antibody VHH B5 experimental SAS data
GASBOR model
Sample: anti-DISC1 single-domain camelid antibody VHH B5 monomer, 14 kDa protein
Buffer: 25 mM Tris, 150 mM NaCl, pH: 7.4
Experiment: SAXS data collected at BM29, ESRF on 2016 Feb 19
Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein. PLoS One 13(1):e0191162 (2018)
...Bradshaw NJ, Prikulis I, Willbold D, Weiergräber OH, Korth C
RgGuinier 1.8 nm
Dmax 8.4 nm
VolumePorod 21 nm3

SASDDM7 – Complex of disrupted-in-Schizophrenia 1 protein (DISC1 12D2) and anti-DISC1 single-domain camelid antibody VHH B5

anti-DISC1 single-domain camelid antibody VHH B5Disrupted- in-schizophrenia 1 (DISC1 12D2) 691-836 experimental SAS data
DAMMIF model
Sample: anti-DISC1 single-domain camelid antibody VHH B5 monomer, 14 kDa protein
Disrupted- in-schizophrenia 1 (DISC1 12D2) 691-836 monomer, 19 kDa protein
Buffer: 25 mM Tris-HCl, 150 mM NaCl, 1mM DTT, pH: 7.4
Experiment: SAXS data collected at BM29, ESRF on 2016 Feb 19
Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein. PLoS One 13(1):e0191162 (2018)
...Bradshaw NJ, Prikulis I, Willbold D, Weiergräber OH, Korth C
RgGuinier 3.1 nm
Dmax 10.4 nm
VolumePorod 77 nm3

SASDUT7 – The tandem SH2 domains of Tyrosine-protein kinase SYK

Tyrosine-protein kinase SYK experimental SAS data
Tyrosine-protein kinase SYK Kratky plot
Sample: Tyrosine-protein kinase SYK monomer, 30 kDa Homo sapiens protein
Buffer: 10 mM HEPES, 150 mM NaCl, 1 mM TCEP, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2023 Nov 13
The mechanism of allosteric activation of SYK kinase derived from multiple phospho-ITAM-bound structures Structure (2024)
Bradshaw W, Harris G, Gileadi O, Katis V
RgGuinier 2.2 nm
Dmax 6.9 nm
VolumePorod 49 nm3

SASDUU7 – The tandem SH2 domains of Tyrosine-protein kinase SYK with a bound FCER1G diphospho-ITAM peptide

Tyrosine-protein kinase SYKHigh affinity immunoglobulin epsilon receptor subunit gamma experimental SAS data
Tyrosine-protein kinase SYK High affinity immunoglobulin epsilon receptor subunit gamma Kratky plot
Sample: Tyrosine-protein kinase SYK monomer, 30 kDa Homo sapiens protein
High affinity immunoglobulin epsilon receptor subunit gamma monomer, 2 kDa Homo sapiens protein
Buffer: 10 mM HEPES, 150 mM NaCl, 1 mM TCEP, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2023 Nov 13
The mechanism of allosteric activation of SYK kinase derived from multiple phospho-ITAM-bound structures Structure (2024)
Bradshaw W, Harris G, Gileadi O, Katis V
RgGuinier 2.1 nm
Dmax 7.0 nm
VolumePorod 54 nm3

SASDUV7 – The tandem SH2 domains of Tyrosine-protein kinase SYK with a bound CD3G diphospho-ITAM peptide

Tyrosine-protein kinase SYKT-cell surface glycoprotein CD3 gamma chain experimental SAS data
Tyrosine-protein kinase SYK T-cell surface glycoprotein CD3 gamma chain Kratky plot
Sample: Tyrosine-protein kinase SYK monomer, 30 kDa Homo sapiens protein
T-cell surface glycoprotein CD3 gamma chain monomer, 3 kDa Homo sapiens protein
Buffer: 10 mM HEPES, 150 mM NaCl, 1 mM TCEP, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2023 Nov 13
The mechanism of allosteric activation of SYK kinase derived from multiple phospho-ITAM-bound structures Structure (2024)
Bradshaw W, Harris G, Gileadi O, Katis V
RgGuinier 2.1 nm
Dmax 7.1 nm
VolumePorod 56 nm3

SASDUW7 – The tandem SH2 domains of Tyrosine-protein kinase SYK with a bound TYROBP diphospho-ITAM peptide

Tyrosine-protein kinase SYKTYRO protein tyrosine kinase-binding protein experimental SAS data
Tyrosine-protein kinase SYK TYRO protein tyrosine kinase-binding protein Kratky plot
Sample: Tyrosine-protein kinase SYK monomer, 30 kDa Homo sapiens protein
TYRO protein tyrosine kinase-binding protein monomer, 2 kDa Homo sapiens protein
Buffer: 10 mM HEPES, 150 mM NaCl, 1 mM TCEP, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2023 Nov 13
The mechanism of allosteric activation of SYK kinase derived from multiple phospho-ITAM-bound structures Structure (2024)
Bradshaw W, Harris G, Gileadi O, Katis V
RgGuinier 2.1 nm
Dmax 7.1 nm
VolumePorod 53 nm3