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11 hits found for Hou

SASDFL4 – C-type lectins CTL4/CTLMA2, 3.1 mg/ml

AGAP005335-PAAGAP005334-PA experimental SAS data
MULTIFOXS model
Sample: AGAP005335-PA monomer, 18 kDa Anopheles gambiae protein
AGAP005334-PA monomer, 18 kDa Anopheles gambiae protein
Buffer: 500 mM NaCl, 20 mM CHES, 0.5 mM CaCl2, 1% glycerol, pH: 9
Experiment: SAXS data collected at Rigaku BioSAXS-2000, Thomas Jefferson University on 2018 Aug 30
Solution structure, glycan specificity and of phenol oxidase inhibitory activity of Anopheles C-type lectins CTL4 and CTLMA2. Sci Rep 9(1):15191 (2019)
...Hou CD, Profitt LA, Singla D, Jennings MP, Valentine AM, Povelones M, Baxter RHG
RgGuinier 2.5 nm
Dmax 8.0 nm
VolumePorod 58 nm3

SASDNF6 – full-length MERS CoV N -protein complexed with 5-propoxy-1H-indole (P4-1 compound)

Nucleoprotein5-(Propoxy)-1H-indole experimental SAS data
CORAL model
Sample: Nucleoprotein dodecamer, 548 kDa Middle East respiratory … protein
5-(Propoxy)-1H-indole dodecamer, 2 kDa
Buffer: 50 mM Tris-HCl, 150 mM NaCl, pH: 8.5
Experiment: SAXS data collected at 23A, Taiwan Photon Source, NSRRC on 2019 Nov 22
Targeting the N-Terminus Domain of the Coronavirus Nucleocapsid Protein Induces Abnormal Oligomerization via Allosteric Modulation Frontiers in Molecular Biosciences 9 (2022)
...Hou M
RgGuinier 6.4 nm
Dmax 22.0 nm
VolumePorod 896 nm3

SASDNG6 – full-length MERS CoV N-protein complexed with 5-Isopropoxy-1H-indole (P4-2 compound)

Nucleoprotein5-Isopropoxy-1H-indole experimental SAS data
CORAL model
Sample: Nucleoprotein dodecamer, 548 kDa Middle East respiratory … protein
5-Isopropoxy-1H-indole dodecamer, 2 kDa
Buffer: 50 mM Tris-HCl, 150 mM NaCl, pH: 8.5
Experiment: SAXS data collected at 23A, Taiwan Photon Source, NSRRC on 2019 Nov 22
Targeting the N-Terminus Domain of the Coronavirus Nucleocapsid Protein Induces Abnormal Oligomerization via Allosteric Modulation Frontiers in Molecular Biosciences 9 (2022)
...Hou M
RgGuinier 6.4 nm
Dmax 22.2 nm
VolumePorod 911 nm3

SASDNH6 – full-length MERS CoV N-protein complexed with 5-(2-fluoroethoxy)-1H-indole (P4-3 compound)

Nucleoprotein5-(2-fluoroethoxy)-1H-indole experimental SAS data
CORAL model
Sample: Nucleoprotein tetramer, 183 kDa Middle East respiratory … protein
5-(2-fluoroethoxy)-1H-indole tetramer, 1 kDa
Buffer: 50 mM Tris-HCl, 150 mM NaCl, pH: 8.5
Experiment: SAXS data collected at 23A, Taiwan Photon Source, NSRRC on 2019 Nov 26
Targeting the N-Terminus Domain of the Coronavirus Nucleocapsid Protein Induces Abnormal Oligomerization via Allosteric Modulation Frontiers in Molecular Biosciences 9 (2022)
...Hou M
RgGuinier 5.7 nm
Dmax 19.1 nm
VolumePorod 477 nm3

SASDNJ6 – full-length MERS CoV N-protein complexed with 5-(2-methoxyethoxy)-1H-indole (P4-4 compound)

Nucleoprotein5-(2-methoxyethoxy)-1H-indole experimental SAS data
CORAL model
Sample: Nucleoprotein tetramer, 183 kDa Middle East respiratory … protein
5-(2-methoxyethoxy)-1H-indole tetramer, 1 kDa
Buffer: 50 mM Tris-HCl, 150 mM NaCl, pH: 8.5
Experiment: SAXS data collected at 23A, Taiwan Photon Source, NSRRC on 2019 Nov 26
Targeting the N-Terminus Domain of the Coronavirus Nucleocapsid Protein Induces Abnormal Oligomerization via Allosteric Modulation Frontiers in Molecular Biosciences 9 (2022)
...Hou M
RgGuinier 6.0 nm
Dmax 18.5 nm
VolumePorod 500 nm3

SASDEB9 – Flagellar brake protein YcgR from Escherichia coli

Flagellar brake protein YcgR experimental SAS data
SASREF model
Sample: Flagellar brake protein YcgR monomer, 29 kDa Escherichia coli protein
Buffer: 20 mM HEPES, 150mM NaCl, 10% glycerol,, pH: 7.5
Experiment: SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2016 Jan 4
Structural insights into the mechanism of c-di-GMP-bound YcgR regulating flagellar motility in Escherichia coli. J Biol Chem 295(3):808-821 (2020)
Hou YJ, Yang WS, Hong Y, Zhang Y, Wang DC, Li DF
RgGuinier 2.6 nm
Dmax 9.1 nm
VolumePorod 44 nm3

SASDEC9 – Flagellar brake protein YcgR in complex with c-di-GMP from Escherichia coli

Flagellar brake protein YcgR in complex with c-di-GMP experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Flagellar brake protein YcgR in complex with c-di-GMP monomer, 29 kDa Escherichia coli protein
Buffer: 20 mM HEPES, 150mM NaCl, 10% glycerol,, pH: 7.5
Experiment: SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2016 Jan 4
Structural insights into the mechanism of c-di-GMP-bound YcgR regulating flagellar motility in Escherichia coli. J Biol Chem 295(3):808-821 (2020)
Hou YJ, Yang WS, Hong Y, Zhang Y, Wang DC, Li DF
RgGuinier 2.2 nm
Dmax 7.3 nm
VolumePorod 44 nm3

SASDCT2 – Bromodomain-containing protein 2 (BRD2) tandem bromodomains

Bromodomain-containing protein 2 experimental SAS data
DAMMIN model
Sample: Bromodomain-containing protein 2 monomer, 43 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, 2% glycerol, 0.5 mM TCEP, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2017 Jan 13
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Mol Cell (2018)
...Hou H, Savitsky P, Uusküla-Reimand L, Gupta GD, Abdouni H, Lin ZY, Tucholska M, Knight JDR, Gonzalez-Badillo B, St-Denis N, Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P, ...
RgGuinier 5.7 nm
Dmax 21.0 nm
VolumePorod 220 nm3

SASDCS2 – Bromodomain-containing protein 3 (BRD3) tandem bromodomains

Bromodomain-containing protein 3 experimental SAS data
DAMMIN model
Sample: Bromodomain-containing protein 3 monomer, 44 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, 2% glycerol, 0.5 mM TCEP, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2017 Jan 13
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Mol Cell (2018)
...Hou H, Savitsky P, Uusküla-Reimand L, Gupta GD, Abdouni H, Lin ZY, Tucholska M, Knight JDR, Gonzalez-Badillo B, St-Denis N, Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P, ...
RgGuinier 6.2 nm
Dmax 21.5 nm
VolumePorod 210 nm3

SASDCR2 – Bromodomain-containing protein 4 (BRD4) tandem bromodomains

Bromodomain-containing protein 4 experimental SAS data
DAMMIN model
Sample: Bromodomain-containing protein 4 monomer, 47 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, 2% glycerol, 0.5 mM TCEP, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2017 Jan 13
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Mol Cell (2018)
...Hou H, Savitsky P, Uusküla-Reimand L, Gupta GD, Abdouni H, Lin ZY, Tucholska M, Knight JDR, Gonzalez-Badillo B, St-Denis N, Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P, ...
RgGuinier 6.3 nm
Dmax 22.0 nm
VolumePorod 251 nm3

SASDCU2 – Bromodomain testis-specific protein (BRDT) tandem bromodomains

Bromodomain testis-specific protein experimental SAS data
DAMMIN model
Sample: Bromodomain testis-specific protein monomer, 43 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, 2% glycerol, 0.5 mM TCEP, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2017 Jan 13
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Mol Cell (2018)
...Hou H, Savitsky P, Uusküla-Reimand L, Gupta GD, Abdouni H, Lin ZY, Tucholska M, Knight JDR, Gonzalez-Badillo B, St-Denis N, Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P, ...
RgGuinier 5.1 nm
Dmax 20.0 nm
VolumePorod 200 nm3